Alterations in serum proteins of rats after immunization with Freund's adjuvant and Bordetella pertussis vaccine

Micheline Pelletier; Serge Montplaisir; Noel R. Rose

doi:10.1007/BF02124339

Alterations in serum proteins of rats after immunization with Freund's adjuvant and Bordetella pertussis vaccine

Micheline Pelletier, Serge Montplaisir, Noel R. Rose

Research output: Contribution to journal › Article › peer-review

Abstract

Immunization is known to modify the level of certain circulating serum proteins. In this study we describe changes in the electrophoretic pattern of serum proteins after immunization with two different antigens: RaTE and BSA incorporated with three different adjuvants: complete Freund's adjuvant, incomplete Freund's adjuvant, and Bordetella pertussis vaccine. Serum albumin and γ globulins were decreased while α₁, α₂, and Β globulins had a tendency to increase. The serum protein modifications were observed as early as 24 h after immunization and were not reversed by histamine or serotonin antagonists. Some physiopathological hypotheses of their possible effects in immunization are discussed.

Original language	English (US)
Pages (from-to)	9-21
Number of pages	13
Journal	Medical Microbiology and Immunology
Volume	160
Issue number	1
DOIs	https://doi.org/10.1007/BF02124339
State	Published - Aug 1974
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Microbiology (medical)

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abstract = "Immunization is known to modify the level of certain circulating serum proteins. In this study we describe changes in the electrophoretic pattern of serum proteins after immunization with two different antigens: RaTE and BSA incorporated with three different adjuvants: complete Freund's adjuvant, incomplete Freund's adjuvant, and Bordetella pertussis vaccine. Serum albumin and γ globulins were decreased while α1, α2, and Β globulins had a tendency to increase. The serum protein modifications were observed as early as 24 h after immunization and were not reversed by histamine or serotonin antagonists. Some physiopathological hypotheses of their possible effects in immunization are discussed.",

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Alterations in serum proteins of rats after immunization with Freund's adjuvant and Bordetella pertussis vaccine

Abstract

ASJC Scopus subject areas

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