Alterations in serum proteins of rats after immunization with Freund's adjuvant and Bordetella pertussis vaccine

Micheline Pelletier, Serge Montplaisir, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Immunization is known to modify the level of certain circulating serum proteins. In this study we describe changes in the electrophoretic pattern of serum proteins after immunization with two different antigens: RaTE and BSA incorporated with three different adjuvants: complete Freund's adjuvant, incomplete Freund's adjuvant, and Bordetella pertussis vaccine. Serum albumin and γ globulins were decreased while α1, α2, and Β globulins had a tendency to increase. The serum protein modifications were observed as early as 24 h after immunization and were not reversed by histamine or serotonin antagonists. Some physiopathological hypotheses of their possible effects in immunization are discussed.

Original languageEnglish (US)
Pages (from-to)9-21
Number of pages13
JournalMedical Microbiology and Immunology
Volume160
Issue number1
DOIs
StatePublished - Aug 1 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Microbiology (medical)

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