Alterations in renal function in psoriasis patients treated with cyclosporine, 5 mg/kg/day.

D. J. Margolis, C. Guzzo, J. Johnson, Gerald Sylvan Lazarus

Research output: Contribution to journalArticle


BACKGROUND: Cyclosporine has been used to treat a variety of cutaneous and immune-mediated diseases. Nephrotoxicity is the most common major adverse side effect. OBJECTIVE: The study was designed to investigate the frequency of alterations in serum creatinine in patients with psoriasis receiving 5 mg/kg/day of cyclosporine. METHODS: Sixteen patients with severe refractory psoriasis received cyclosporine, 5 mg/kg/day, for 12 weeks. Serum creatinine was evaluated with respect to each patient's baseline. RESULTS: Serum creatinine levels remained in the normal range, but 10 of 16 patients had a 30% elevation and 5 of 16 patients had a 50% elevation of serum creatinine compared with the patient's baseline value. CONCLUSION: These results indicate that a significant elevation in serum creatinine occurs in many patients who receive cyclosporine for psoriasis.

Original languageEnglish (US)
Pages (from-to)195-197
Number of pages3
JournalJournal of the American Academy of Dermatology
Issue number2 Pt 1
Publication statusPublished - Feb 1992
Externally publishedYes


ASJC Scopus subject areas

  • Dermatology

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