Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice

Reyhan Westbrook, Michael S. Bonkowski, April D. Strader, Andrzej Bartke

Research output: Contribution to journalArticlepeer-review

Abstract

Growth hormone (GH) signaling influences longevity in mice, with decreased GH signaling associated with longer life span and increased GH signaling with shortened life span. A proposed mechanism through which GH signaling influences life span postulates that decreased GH signaling lowers metabolic rate, thus slowing aging by decreasing production of damaging free radicals. The influence of altered GH signaling on metabolism was tested by monitoring oxygen consumption (VO2), respiratory quotient (RQ), and heat production in long-lived GH receptor knockout (GHRKO) and Ames dwarf mice, and short-lived bovine GH-overexpressing transgenic (bGH TG) mice. Intriguingly, both GHRKO and Ames dwarf mice have increased VO2 and heat per gram body weight, and decreased RQ, whereas bGH TG mice have decreased VO2 and heat per gram body weight and increased RQ. In conclusion, decreased GH signaling associates with increased metabolism per body weight and may beneficially affect mitochondrial flexibility by increasing the capacity for fat oxidation; generally, GH excess produces opposite metabolic effects.

Original languageEnglish (US)
Pages (from-to)443-451
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

Keywords

  • Altered growth hormone signaling
  • Metabolism
  • Oxygen consumption
  • Respiratory quotient
  • Thyroid hormone

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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