Alterations in DNA methylation in human colon neoplasia

Andrew P. Feinberg; Bert Vogelstein

doi:10.1002/ssu.2980030304

Alterations in DNA methylation in human colon neoplasia

Andrew P. Feinberg, Bert Vogelstein

Howard Hughes Medical Institution

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A review of studies on DNA methylation in colonic neoplasia is presented. Hypomethylation of a wide variety of genes from throughout the genome was seen in all colon cancers studied. These changes preceded malignancy because benign adenomas were also affected.

Original language	English (US)
Pages (from-to)	149-151
Number of pages	3
Journal	Seminars in surgical oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1002/ssu.2980030304
State	Published - 1987

Keywords

hypomethylation
molecular biology
polyps

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/ssu.2980030304

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title = "Alterations in DNA methylation in human colon neoplasia",

abstract = "A review of studies on DNA methylation in colonic neoplasia is presented. Hypomethylation of a wide variety of genes from throughout the genome was seen in all colon cancers studied. These changes preceded malignancy because benign adenomas were also affected.",

keywords = "hypomethylation, molecular biology, polyps",

author = "Feinberg, {Andrew P.} and Bert Vogelstein",

year = "1987",

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volume = "3",

pages = "149--151",

journal = "Seminars in surgical oncology",

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T1 - Alterations in DNA methylation in human colon neoplasia

AU - Feinberg, Andrew P.

AU - Vogelstein, Bert

PY - 1987

Y1 - 1987

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AB - A review of studies on DNA methylation in colonic neoplasia is presented. Hypomethylation of a wide variety of genes from throughout the genome was seen in all colon cancers studied. These changes preceded malignancy because benign adenomas were also affected.

KW - hypomethylation

KW - molecular biology

KW - polyps

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DO - 10.1002/ssu.2980030304

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AN - SCOPUS:0023254051

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JO - Seminars in surgical oncology

JF - Seminars in surgical oncology

IS - 3

ER -

Alterations in DNA methylation in human colon neoplasia

Abstract

Keywords

ASJC Scopus subject areas

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