Alterations in cardiac and pulmonary function in pediatric rapid human immunodeficiency virus type 1 disease progressors. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Study Group.

W. T. Shearer, S. E. Lipshultz, K. A. Easley, K. McIntosh, J. Pitt, Thomas C Quinn, M. Kattan, J. Goldfarb, E. Cooper, Y. Bryson, A. Kovacs, J. T. Bricker, H. Peavy, R. B. Mellins, N. Heart, L. B. Institute

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Infants with human immunodeficiency virus type 1 (HIV-1) can be divided into rapid progressors (RPs) and non-rapid progressors (non-RPs) based on symptoms and immunologic status, but detailed information about cardiac and pulmonary function in RP and non-RP children needs to be adequately described. METHODOLOGY: Cardiac, pulmonary, and immunologic data and HIV-1 RNA burden were periodically measured in 3 groups: group I, 205 vertically infected children enrolled from 1990 to 1994 and followed through 1996; group II, a prospectively studied cohort enrolled at birth that included 93 infected (group IIa); and 463 noninfected infants (group IIb). RESULTS: Mean respiratory rates were generally higher in group IIa RP than non-RP children throughout the period of follow-up, achieving statistical signifance at 1 month, 12 months, 24 months, 30 months, and 48 months of follow-up. Non-RP and group IIb (HIV-uninfected children) had similar mean respiratory rates from birth to 5 years of age. Significant differences in mean respiratory rates were found between group I RP and non-RP at 7 age intervals over the first 6 years of life. Mean respiratory rates were higher in RP than in non-RP at

Original languageEnglish (US)
JournalPediatrics
Volume105
Issue number1
StatePublished - Jan 2000
Externally publishedYes

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Virus Diseases
Respiratory Rate
HIV-1
HIV
Pediatrics
Lung
Parturition
RNA

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Alterations in cardiac and pulmonary function in pediatric rapid human immunodeficiency virus type 1 disease progressors. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Study Group. / Shearer, W. T.; Lipshultz, S. E.; Easley, K. A.; McIntosh, K.; Pitt, J.; Quinn, Thomas C; Kattan, M.; Goldfarb, J.; Cooper, E.; Bryson, Y.; Kovacs, A.; Bricker, J. T.; Peavy, H.; Mellins, R. B.; Heart, N.; Institute, L. B.

In: Pediatrics, Vol. 105, No. 1, 01.2000.

Research output: Contribution to journalArticle

Shearer, WT, Lipshultz, SE, Easley, KA, McIntosh, K, Pitt, J, Quinn, TC, Kattan, M, Goldfarb, J, Cooper, E, Bryson, Y, Kovacs, A, Bricker, JT, Peavy, H, Mellins, RB, Heart, N & Institute, LB 2000, 'Alterations in cardiac and pulmonary function in pediatric rapid human immunodeficiency virus type 1 disease progressors. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Study Group.', Pediatrics, vol. 105, no. 1.
Shearer, W. T. ; Lipshultz, S. E. ; Easley, K. A. ; McIntosh, K. ; Pitt, J. ; Quinn, Thomas C ; Kattan, M. ; Goldfarb, J. ; Cooper, E. ; Bryson, Y. ; Kovacs, A. ; Bricker, J. T. ; Peavy, H. ; Mellins, R. B. ; Heart, N. ; Institute, L. B. / Alterations in cardiac and pulmonary function in pediatric rapid human immunodeficiency virus type 1 disease progressors. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Study Group. In: Pediatrics. 2000 ; Vol. 105, No. 1.
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AU - Lipshultz, S. E.

AU - Easley, K. A.

AU - McIntosh, K.

AU - Pitt, J.

AU - Quinn, Thomas C

AU - Kattan, M.

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AU - Cooper, E.

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AU - Kovacs, A.

AU - Bricker, J. T.

AU - Peavy, H.

AU - Mellins, R. B.

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