Alterations in [3H]desmethylimipramine binding in the aged rat brain: an in vitro autoradiographic demonstration

P. R. Rapp; R. F. Fanelli; M. McGuire; R. A. Rosenberg; M. Gallagher

doi:10.1016/0304-3940(87)90665-3

Alterations in [³H]desmethylimipramine binding in the aged rat brain: an in vitro autoradiographic demonstration

P. R. Rapp, R. F. Fanelli, M. McGuire, R. A. Rosenberg, M. Gallagher

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Using in vitro autoradiographic receptor binding, the present report provides a descriptive analysis of [³H]desmethylimipramine ([³H]DMI) binding in the aged rat brain. Small circular patches of intense [³H]DMI binding were present within the caudate nucleus in every aged brain examined. Occasionally, similar patches of label were present in restricted cortical regions of aged brains. Comparable patches of [³H]DMI binding were never observed in young brains used in these investigations. Additional evidence suggests that these age-dependent changes in [³H]DMI binding are anatomically restricted to the loci indicated above.

Original language	English (US)
Pages (from-to)	17-22
Number of pages	6
Journal	Neuroscience Letters
Volume	79
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(87)90665-3
State	Published - Aug 18 1987
Externally published	Yes

Keywords

Aging
In vitro autoradiography
Rat
[H]Desmethylimipramine binding

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0304-3940(87)90665-3

Cite this

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title = "Alterations in [3H]desmethylimipramine binding in the aged rat brain: an in vitro autoradiographic demonstration",

abstract = "Using in vitro autoradiographic receptor binding, the present report provides a descriptive analysis of [3H]desmethylimipramine ([3H]DMI) binding in the aged rat brain. Small circular patches of intense [3H]DMI binding were present within the caudate nucleus in every aged brain examined. Occasionally, similar patches of label were present in restricted cortical regions of aged brains. Comparable patches of [3H]DMI binding were never observed in young brains used in these investigations. Additional evidence suggests that these age-dependent changes in [3H]DMI binding are anatomically restricted to the loci indicated above.",

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T2 - an in vitro autoradiographic demonstration

AU - Rapp, P. R.

AU - Fanelli, R. F.

AU - McGuire, M.

AU - Rosenberg, R. A.

AU - Gallagher, M.

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AB - Using in vitro autoradiographic receptor binding, the present report provides a descriptive analysis of [3H]desmethylimipramine ([3H]DMI) binding in the aged rat brain. Small circular patches of intense [3H]DMI binding were present within the caudate nucleus in every aged brain examined. Occasionally, similar patches of label were present in restricted cortical regions of aged brains. Comparable patches of [3H]DMI binding were never observed in young brains used in these investigations. Additional evidence suggests that these age-dependent changes in [3H]DMI binding are anatomically restricted to the loci indicated above.

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