Alterations in [3H]desmethylimipramine binding in the aged rat brain

an in vitro autoradiographic demonstration

P. R. Rapp, R. F. Fanelli, M. McGuire, R. A. Rosenberg, Michela Gallagher

Research output: Contribution to journalArticle

Abstract

Using in vitro autoradiographic receptor binding, the present report provides a descriptive analysis of [3H]desmethylimipramine ([3H]DMI) binding in the aged rat brain. Small circular patches of intense [3H]DMI binding were present within the caudate nucleus in every aged brain examined. Occasionally, similar patches of label were present in restricted cortical regions of aged brains. Comparable patches of [3H]DMI binding were never observed in young brains used in these investigations. Additional evidence suggests that these age-dependent changes in [3H]DMI binding are anatomically restricted to the loci indicated above.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalNeuroscience Letters
Volume79
Issue number1-2
DOIs
StatePublished - Aug 18 1987
Externally publishedYes

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Desipramine
Brain
Caudate Nucleus
In Vitro Techniques

Keywords

  • Aging
  • In vitro autoradiography
  • Rat
  • [H]Desmethylimipramine binding

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alterations in [3H]desmethylimipramine binding in the aged rat brain : an in vitro autoradiographic demonstration. / Rapp, P. R.; Fanelli, R. F.; McGuire, M.; Rosenberg, R. A.; Gallagher, Michela.

In: Neuroscience Letters, Vol. 79, No. 1-2, 18.08.1987, p. 17-22.

Research output: Contribution to journalArticle

Rapp, P. R. ; Fanelli, R. F. ; McGuire, M. ; Rosenberg, R. A. ; Gallagher, Michela. / Alterations in [3H]desmethylimipramine binding in the aged rat brain : an in vitro autoradiographic demonstration. In: Neuroscience Letters. 1987 ; Vol. 79, No. 1-2. pp. 17-22.
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