Alteration of gene expression in Down's syndrome (DS) brains: Its significance in neurodegeneration

Research output: Contribution to journalReview article

Abstract

Several groups have reported pro-apoptotic alteration of gene expression in Down's syndrome (DS) brains. Aged DS brains manifest a similar neuropathology to Alzheimer's disease (AD), including the presence of senile plaques (SP) and neurofibrillary tangles (NFT). Although it is controversial if neurodegenerative processes play a pathological role in DS brains, evidence such as cortical neurons from fetal DS brains showing vulnerability to cell death when compared with neurons from control subjects supports this point of view. In this chapter, we review the reports that demonstrate pro-apoptotic alteration of gene expression in DS brains. In addition to the pathogenic genes on chromosome 21, such as amyloid precursor protein (APP) and CuZn-superoxide dismutase (SOD1), other genes which associate with p53, or with processes for protein folding have been frequently found.

Original languageEnglish (US)
Pages (from-to)361-371
Number of pages11
JournalJournal of Neural Transmission, Supplement
Issue number61
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Alteration of gene expression in Down's syndrome (DS) brains: Its significance in neurodegeneration'. Together they form a unique fingerprint.

  • Cite this