ALSUntangled #63: ketogenic diets

Richard Bedlack, Paul E. Barkhaus, Benjamin Barnes, Morgan Beauchamp, Tulio Bertorini, Mark B. Bromberg, Gregory T. Carter, Vinay Chaudry, Merit Cudkowicz, Ce Jackson, Gleb Levitsky, Isaac Lund, Christopher McDermott, Steven Novella, Natasha Olby, Lyle Ostrow, Gary L. Pattee, Terry Heiman-Patterson, Dylan Ratner, Kristiana SalmonSusan Steves, Mark Terrelonge, Paul Wicks, Anne Marie Wills

Research output: Contribution to journalReview articlepeer-review

Abstract

ALSUntangled reviews alternative and off label treatments with a goal of helping patients make more informed decisions about them. Here we review ketogenic diets. We shows that these have plausible mechanisms, including augmenting cellular energy balance and reducing excitotoxicity, neuroinflammation and oxidative stress. We review a mouse model study, anecdotal reports and trials in ALS and other diseases. We conclude that there is yet not enough data to recommend ketogenic diets for patients with ALS, especially in light of the many side effects these can have.

Keywords

  • Ketone
  • alsuntangled
  • ketogenic diet
  • mitochondria
  • therapy
  • transgenic animals

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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