Alpha-thalassemia: Prenatal diagnosis and neonatal implications

Mark C. Maberry, Victor R. Klein, Corinne Boehm, Tina C. Warren, Larry C. Gilstrap

Research output: Contribution to journalArticle

Abstract

Homozygous α-thalassemia major, or Bart's hemoglobinopathy, is the most common etiology of nonimmune hydrops in those of Oriental descent. The prenatal diagnosis can now be made utilizing DNA hybridization technique from fetal cells obtained by either amniocentesis or chorionic villus sampling. A case is reviewed documenting the utilization of DNA studies in managing patients known or suspected to have a history of α-thalassemia major.

Original languageEnglish (US)
Pages (from-to)356-358
Number of pages3
JournalAmerican journal of perinatology
Volume7
Issue number4
DOIs
StatePublished - Oct 1990

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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    Maberry, M. C., Klein, V. R., Boehm, C., Warren, T. C., & Gilstrap, L. C. (1990). Alpha-thalassemia: Prenatal diagnosis and neonatal implications. American journal of perinatology, 7(4), 356-358. https://doi.org/10.1055/s-2007-999522