Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: Evidence from the Baltimore Longitudinal Study of Aging (BLSA)

Irina Mikolaenko, Olga Pletnikova, Claudia H. Kawas, Richard O'Brien, Susan M. Resnick, Barbara Crain, Juan C Troncoso

Research output: Contribution to journalArticle

Abstract

Alpha-synuclein (α-synuclein) lesions are characteristic of idiopathic Parkinson disease (PD) and other α-synucleinopathies. To study the frequency of α-synuclein lesions in normal aging and how frequently they coexist with lesions of Alzheimer disease (AD), we examined the autopsy brains from normal and demented subjects in the Baltimore Longitudinal Study of Aging (BLSA) (n = 117). We found that the overall frequency of α-synuclein lesions was 25%, with 100% in 7 cases of PD, 31.5% in 56 cases with AD lesions, and 8.3% among 36 older control brains. Among brains with AD lesions, the frequency of α-synuclein pathology was higher in those with higher scores for neuritic plaques, but not in those with higher scores for neurofibrillary tangles. Our observations indicate that α-synuclein lesions are uncommon in aged control subjects. Finally, the coexistence of Aβ amyloid and α-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Aβ and α-synuclein may be similar.

Original languageEnglish (US)
Pages (from-to)156-162
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume64
Issue number2
StatePublished - Feb 2005

Fingerprint

Synucleins
alpha-Synuclein
Baltimore
Parkinson Disease
Longitudinal Studies
Alzheimer Disease
Brain
Pathology
Neurofibrillary Tangles
Amyloid Plaques
Amyloid
Autopsy

Keywords

  • α-synucleinopathy
  • Aging
  • Alzheimer disease
  • Lewy body
  • Lewy neurite
  • Parkinson disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease : Evidence from the Baltimore Longitudinal Study of Aging (BLSA). / Mikolaenko, Irina; Pletnikova, Olga; Kawas, Claudia H.; O'Brien, Richard; Resnick, Susan M.; Crain, Barbara; Troncoso, Juan C.

In: Journal of Neuropathology and Experimental Neurology, Vol. 64, No. 2, 02.2005, p. 156-162.

Research output: Contribution to journalArticle

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