Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia.

Mahmood Amiry-Moghaddam, Rong Xue, Finn Mogens Haug, John D. Neely, Anish Bhardwaj, Peter Agre, Marvin E. Adams, Stanley C. Froehner, Susumu Mori, Ole P. Ottersen

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