TY - JOUR
T1 - Allopurinol-Induced Orotidinuria
AU - Tuchman, Mendel
AU - Hauser, Elizabeth R.
AU - Finkelstein, Janice E.
AU - Valle, David
AU - Brusilow, Saul W.
PY - 1990/11/8
Y1 - 1990/11/8
N2 - To the Editor: In their article (June 7 issue),1 Hauser et al. provide convincing evidence that measurement of urinary orotidine excretion after the administration of allopurinol is a simple and reliable test for the identification of women who are heterozygous for X-linked ornithine carbamoyltransferase deficiency. The authors go one step further and state that this test may also be diagnostic in women (and I would think also in men) whose medical history is compatible with such a deficiency. Although I agree with this last statement, I think that it needs clarification. The mechanism for orotic aciduria in ornithine carbamoyltransferase deficiency.
AB - To the Editor: In their article (June 7 issue),1 Hauser et al. provide convincing evidence that measurement of urinary orotidine excretion after the administration of allopurinol is a simple and reliable test for the identification of women who are heterozygous for X-linked ornithine carbamoyltransferase deficiency. The authors go one step further and state that this test may also be diagnostic in women (and I would think also in men) whose medical history is compatible with such a deficiency. Although I agree with this last statement, I think that it needs clarification. The mechanism for orotic aciduria in ornithine carbamoyltransferase deficiency.
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U2 - 10.1056/NEJM199011083231917
DO - 10.1056/NEJM199011083231917
M3 - Letter
C2 - 2215627
AN - SCOPUS:0025123423
SN - 0028-4793
VL - 323
SP - 1352
EP - 1353
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 19
ER -