Allopurinol-Induced Orotidinuria

Mendel Tuchman, Elizabeth R. Hauser, Janice E. Finkelstein, David Valle, Saul W. Brusilow

Research output: Contribution to journalLetterpeer-review

Abstract

To the Editor: In their article (June 7 issue),1 Hauser et al. provide convincing evidence that measurement of urinary orotidine excretion after the administration of allopurinol is a simple and reliable test for the identification of women who are heterozygous for X-linked ornithine carbamoyltransferase deficiency. The authors go one step further and state that this test may also be diagnostic in women (and I would think also in men) whose medical history is compatible with such a deficiency. Although I agree with this last statement, I think that it needs clarification. The mechanism for orotic aciduria in ornithine carbamoyltransferase deficiency.

Original languageEnglish (US)
Pages (from-to)1352-1353
Number of pages2
JournalNew England Journal of Medicine
Volume323
Issue number19
DOIs
StatePublished - Nov 8 1990

ASJC Scopus subject areas

  • Medicine(all)

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