Alloimplant extrusion: A link between invertebrate and vertebrate defense systems?

William M. Baldwin; Nicholas Cohen

doi:10.1007/BF01572276

Alloimplant extrusion: A link between invertebrate and vertebrate defense systems?

William M. Baldwin, Nicholas Cohen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An immunologically dependent encapsulation-extrusion mechanism causes salamanders to extrude partially rejected subcutaneous implants of normal and neoplastic allogeneic tissues. This reaction occurs more frequently in sensitized hosts and is preferentially expressed when animals are implanted and maintained in the cold and then transferred to the warm. These data suggest the hypothesis that vertebrate cellular and humoral immunity may have evolved by modifying and increasing the survival value of foreign body reactions of primitive invertebrates.

Original language	English (US)
Pages (from-to)	73-79
Number of pages	7
Journal	Immunogenetics
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/BF01572276
State	Published - Dec 1975
Externally published	Yes

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/BF01572276

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title = "Alloimplant extrusion: A link between invertebrate and vertebrate defense systems?",

abstract = "An immunologically dependent encapsulation-extrusion mechanism causes salamanders to extrude partially rejected subcutaneous implants of normal and neoplastic allogeneic tissues. This reaction occurs more frequently in sensitized hosts and is preferentially expressed when animals are implanted and maintained in the cold and then transferred to the warm. These data suggest the hypothesis that vertebrate cellular and humoral immunity may have evolved by modifying and increasing the survival value of foreign body reactions of primitive invertebrates.",

author = "Baldwin, {William M.} and Nicholas Cohen",

year = "1975",

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doi = "10.1007/BF01572276",

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PY - 1975/12

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N2 - An immunologically dependent encapsulation-extrusion mechanism causes salamanders to extrude partially rejected subcutaneous implants of normal and neoplastic allogeneic tissues. This reaction occurs more frequently in sensitized hosts and is preferentially expressed when animals are implanted and maintained in the cold and then transferred to the warm. These data suggest the hypothesis that vertebrate cellular and humoral immunity may have evolved by modifying and increasing the survival value of foreign body reactions of primitive invertebrates.

AB - An immunologically dependent encapsulation-extrusion mechanism causes salamanders to extrude partially rejected subcutaneous implants of normal and neoplastic allogeneic tissues. This reaction occurs more frequently in sensitized hosts and is preferentially expressed when animals are implanted and maintained in the cold and then transferred to the warm. These data suggest the hypothesis that vertebrate cellular and humoral immunity may have evolved by modifying and increasing the survival value of foreign body reactions of primitive invertebrates.

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Alloimplant extrusion: A link between invertebrate and vertebrate defense systems?

Abstract

ASJC Scopus subject areas

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