Allogeneic hematopoietic cell transplantation improves outcome of adults with t(6;9) acute myeloid leukemia: Results from an international collaborative study

Sabine Kayser, Robert K. Hills, Marlise R. Luskin, Andrew M. Brunner, Christine Terré, Jörg Westermann, Kamal Menghrajani, Carole Shaw, Maria R. Baer, Michelle A. Elliott, Alexander E. Perl, Zdeněk Ráčil, Jiri Mayer, Pavel Zak, Tomas Szotkowski, Stéphane de Botton, David Grimwade, Karin Mayer, Roland B. Walter, Alwin KrämerAlan K. Burnett, Anthony D. Ho, Uwe Platzbecker, Christian Thiede, Gerhard Ehninger, Richard M. Stone, Christoph Röllig, Martin S. Tallman, Elihu H. Estey, Carsten Müller-Tidow, Nigel H. Russell, Richard F. Schlenk, Mark J. Levis

Research output: Contribution to journalArticle

Abstract

A cute myeloid leukemia (AML) with t(6;9)(p22;q34) is a distinct entity accounting for 1-2% of AML cases. A substantial proportion of these patients have a concomitant FLT3-ITD. While outcomes are dismal with intensive chemotherapy, limited evidence suggests allogeneic hematopoietic cell transplantation (allo-HCT) may improve survival if performed early during first complete remission. We report on a cohort of 178 patients with t(6;9)(p22;q34) within an international, multicenter collaboration. Median age was 46 years (range: 16-76), AML was de novo in 88%, FLT3-ITD was present in 62%, and additional cytogenetic abnormalities in 21%. Complete remission was achieved in 81% (n=144), including 14 patients who received high-dose cytarabine after initial induction failure. With a median follow up of 5.43 years, estimated overall survival at five years was 38% (95%CI: 31-47%). Allo-HCT was performed in 117 (66%) patients, including 89 in first complete remission. Allo-HCT in first complete remission was associated with higher 5-year relapse-free and overall survival as compared to consolidation chemotherapy: 45% (95%CI: 35-59%) and 53% (95%CI: 42-66%) versus 7% (95%CI: 3-19%) and 23% (95%CI: 13-38%), respectively. For patients undergoing allo-HCT, there was no difference in overall survival rates at five years according to whether it was performed in first [53% (95%CI: 42-66%)], or second [58% (95%CI: 31-100%); n=10] complete remission or with active disease/relapse [54% (95%CI: 34-84%); n=18] (P=0.67). Neither FLT3-ITD nor additional chromosomal abnormalities impacted survival. In conclusion, outcomes of t(6;9)(p22;q34) AML are poor with chemotherapy, and can be substantially improved with allo-HCT.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalHaematologica
Volume105
Issue number1
DOIs
StatePublished - Jan 1 2020

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Allogeneic hematopoietic cell transplantation improves outcome of adults with t(6;9) acute myeloid leukemia: Results from an international collaborative study'. Together they form a unique fingerprint.

  • Cite this

    Kayser, S., Hills, R. K., Luskin, M. R., Brunner, A. M., Terré, C., Westermann, J., Menghrajani, K., Shaw, C., Baer, M. R., Elliott, M. A., Perl, A. E., Ráčil, Z., Mayer, J., Zak, P., Szotkowski, T., de Botton, S., Grimwade, D., Mayer, K., Walter, R. B., ... Levis, M. J. (2020). Allogeneic hematopoietic cell transplantation improves outcome of adults with t(6;9) acute myeloid leukemia: Results from an international collaborative study. Haematologica, 105(1), 161-169. https://doi.org/10.3324/haematol.2018.208678