Allogeneic bone marrow transplantation in patients with sensitive low-grade lymphoma or mantle cell lymphoma

Jesüs G. Berdeja, Richard J. Jones, Marianna L. Zahurak, Steven Piantadosi, Ross A. Abrams, Michael J. Borowitz, Georgia B. Vogelsang, Stephen J. Noga, Richard F. Ambinder, Ian W. Flinn

Research output: Contribution to journalArticle

Abstract

Purpose: To report survival outcomes of allogeneic BMT in patients with low-grade lymphoma or mantle cell lymphoma (MCL). Patients and Methods: Thirty-five patients with low-grade lymphoma (48%), chronic lymphocytic leukemia (26%), or MCL (26%) underwent myeloablative allogeneic BMT from HLA-identical siblings at the Johns Hopkins Oncology Center. Patients had a median age of 46 years, a median of 2 prior treatments, and 31% were in complete remission at the time of transplantation. The preparative regimen was cyclophosphamide/total body irradiation for most patients. All grafts were T-cell depleted by counter flow centrifugal elutriation with CD34+ augmentation. Results: The incidence of acute GVHD grade>2 was 6% and of grades 1 to 2 was 37%. The incidence of chronic GVHD was 6%. The median follow-up time was 25 months. The rate of event-free survival (EFS) was 50% (95% confidence interval [CI], 33%-66%). Only 1 patient relapsed. The transplantation-related mortality (TRM) was 46% for all patients. The TRM was 86% for patients with resistant disease and 14% for patients with sensitive disease and <2 prior treatments; rates of EFS were 0% (95% CI, 0%-0%) and 79% (95% CI, 47%-93%), respectively. Conclusion: These data show that, with T-cell depletion, the TRM and relapse rates are modest for patients with sensitive disease and <2 prior treatment courses. Thus, if there is a role for allogeneic BMT in the management of patients with these tumors, it is early in the course of the disease.

Original languageEnglish (US)
Pages (from-to)561-567
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume7
Issue number10
DOIs
StatePublished - Jan 1 2001

Keywords

  • AlloBMT
  • Chronic lymphocytic leukemia
  • Event-free survival
  • Follicular lymphoma
  • Graft-versus-lymphoma effect
  • Mantle cell lymphoma
  • Transplantation-related morbidity

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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