Alloantibody induced platelet responses in transplants: Potent mediators in small packages

Hsiao Hsuan Kuo, Craig N. Morrell, William M. Baldwin

Research output: Contribution to journalArticle

Abstract

The early histological studies of organ allografts noted platelets attached to vascular endothelium. Platelets adhere to vessels before any morphological evidence of endothelial injury. Subsequently, in vitro and in vivo experiments have demonstrated that alloantibodies can induce exocytosis of von Willebrand factor and P-selectin from endothelial cells and attachment of platelets within minutes. Platelets also adhere to and stimulate leukocytes. These interactions are increased by complement activation. After attachment platelets degranulate, releasing preformed mediators. Some chemokines stored together in platelet granules can form heteromers with synergistic functions. Heteromers containing platelet factor 4 (PF4; CXCL4) are specific to platelets and provide insights to unique platelet functions and opportunities for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1233-1238
Number of pages6
JournalHuman Immunology
Volume73
Issue number12
DOIs
StatePublished - Dec 2012
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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