Allergy to insect sting. III. Allergenic cross reactivity among the vespid venoms

F. Kern, A. K. Sobotka, Martin D. Valentine, A. W. Benton, L. M. Lichtenstein

Research output: Contribution to journalArticle

Abstract

Recent reports have indicated that venoms may be more beneficial than whole body extracts for the diagnosis and treatment of Hymenoptera sensitive patients. These studies were undertaken to determine the cross reactivity among the vespid venoms. Eighteen patients who were anaphylactically sensitive to vespid venoms were studied using in vitro leukocyte histamine release. The results (venom concentration for 50% histamine release) were analyzed by linear regression analysis; there was no allergenic cross reactivity between any of the venoms, except for a modest association between yellow hornet and white hornet venom. In spite of this result 13 of the 18 patients studied were sensitive to 3 or 4 of the venoms tested. There is no clear explanation for this observation, but it suggests the existence of multiple major allergens in the vespid venoms, some of which are cross reactive. Since immunotherapy with inappropriate proteins may lead to the development of IgE and the possibility of clinical sensitivity and since the majority of patients were not sensitive to all venom preparations, the authors suggest that appropriate diagnostic studies be carried out before the institution of therapy.

Original languageEnglish (US)
Pages (from-to)554-559
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume57
Issue number6
DOIs
StatePublished - 1976

Fingerprint

Wasp Venoms
Insect Bites and Stings
Venoms
Hypersensitivity
Wasps
Histamine Release
Hymenoptera
Immunotherapy
Allergens
Immunoglobulin E
Linear Models
Leukocytes
Regression Analysis
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Allergy to insect sting. III. Allergenic cross reactivity among the vespid venoms. / Kern, F.; Sobotka, A. K.; Valentine, Martin D.; Benton, A. W.; Lichtenstein, L. M.

In: The Journal of Allergy and Clinical Immunology, Vol. 57, No. 6, 1976, p. 554-559.

Research output: Contribution to journalArticle

Kern, F. ; Sobotka, A. K. ; Valentine, Martin D. ; Benton, A. W. ; Lichtenstein, L. M. / Allergy to insect sting. III. Allergenic cross reactivity among the vespid venoms. In: The Journal of Allergy and Clinical Immunology. 1976 ; Vol. 57, No. 6. pp. 554-559.
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