Allergic diseases in the lungs.

Research output: Contribution to journalArticle

Abstract

Four basic immune reactions in the lung are fundamental to our understanding of allergic lung diseases. The first, immediate hypersensitivity, principally involves airway obstruction because of hypersecretion and bronchospasm. Resulting roentgenographic changes are those of large and small airway disease. The second reaction, cytotoxic antibody-mediated disease, produces air space filling by hemorrhage. The third form, immune complex-mediated hypersensitivity, causes mixed patchy consolidation and interstitial roentgenographic patterns caused by inflammation stimulated by antigen-antibody complexes. Fourth, cell-mediated immunity usually produces a granulomatous reaction, roentgenographically manifest by nodules, masses, and enlarged lymph nodes. Applying our understanding of these four basic reactions permits understanding the common allergic disease of the lungs: hypersensitivity pneumonitis, asthma, allergic bronchopulmonary fungal disease, chronic eosinophilic pneumonia, hypereosinophilic syndrome, Goodpasture's syndrome and idiopathic pulmonary hemosiderosis (IPH), Wegener's granulomatosis, and allergic granulomatosis (Churg-Strauss disease). The clinical, pathologic, and roentgenographic manifestations of these diseases are explained and related to the basic immune mechanisms.

Original languageEnglish (US)
Pages (from-to)159-176
Number of pages18
JournalCritical Reviews in Diagnostic Imaging
Volume25
Issue number2
StatePublished - 1986
Externally publishedYes

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Lung Diseases
Antigen-Antibody Complex
Anti-Glomerular Basement Membrane Disease
Hypereosinophilic Syndrome
Churg-Strauss Syndrome
Extrinsic Allergic Alveolitis
Immediate Hypersensitivity
Bronchial Spasm
Granulomatosis with Polyangiitis
Mycoses
Airway Obstruction
Cellular Immunity
Hypersensitivity
Asthma
Lymph Nodes
Air
Hemorrhage
Inflammation
Lung
Antibodies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Allergic diseases in the lungs. / Feigin, David.

In: Critical Reviews in Diagnostic Imaging, Vol. 25, No. 2, 1986, p. 159-176.

Research output: Contribution to journalArticle

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