Allergens of Hymenopteran Venoms

Research output: Contribution to journalArticle

Abstract

Venoms of the Hymenoptera are mixtures of several antigens with nonimmunogenic small peptides and vasoactive amines. Limited local toxicity occurs with stings; systemic reactions to venoms are mediated by IgE antibodies and can be prevented by immunization with the appropriate venom. Skin testing with venoms detects the sensitized state, and a positive test predicts a 50 to 60% risk of an allergic response to a future sting. Because considerable cross-reactivity exists between vespid venom allergens, choice of correct venom(s) for immunotherapy will not always be indicated by skin-testing with whole, unfractionated venom. Further efforts at skin testing with individual venom antigens may help to resolve problems regarding choice of venoms for immunotherapy.

Original languageEnglish (US)
Pages (from-to)137-148
Number of pages12
JournalClinical Reviews in Allergy
Volume5
Issue number2
DOIs
StatePublished - May 1987

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Venoms
Allergens
Bites and Stings
Immunotherapy
Skin
Wasp Venoms
Antigens
Hymenoptera
Immunoglobulin E
Amines
Immunization
Peptides
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Medicine(all)

Cite this

Allergens of Hymenopteran Venoms. / King, T. P.; Valentine, Martin D.

In: Clinical Reviews in Allergy, Vol. 5, No. 2, 05.1987, p. 137-148.

Research output: Contribution to journalArticle

King, T. P. ; Valentine, Martin D. / Allergens of Hymenopteran Venoms. In: Clinical Reviews in Allergy. 1987 ; Vol. 5, No. 2. pp. 137-148.
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