Allergens of Hymenopteran Venoms

T. P. King; Martin D. Valentine

doi:10.1007/BF02991203

Allergens of Hymenopteran Venoms

T. P. King, Martin D. Valentine

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Venoms of the Hymenoptera are mixtures of several antigens with nonimmunogenic small peptides and vasoactive amines. Limited local toxicity occurs with stings; systemic reactions to venoms are mediated by IgE antibodies and can be prevented by immunization with the appropriate venom. Skin testing with venoms detects the sensitized state, and a positive test predicts a 50 to 60% risk of an allergic response to a future sting. Because considerable cross-reactivity exists between vespid venom allergens, choice of correct venom(s) for immunotherapy will not always be indicated by skin-testing with whole, unfractionated venom. Further efforts at skin testing with individual venom antigens may help to resolve problems regarding choice of venoms for immunotherapy.

Original language	English (US)
Pages (from-to)	137-148
Number of pages	12
Journal	Clinical Reviews In Allergy
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/BF02991203
State	Published - May 1987

ASJC Scopus subject areas

Immunology and Allergy

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10.1007/BF02991203

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AB - Venoms of the Hymenoptera are mixtures of several antigens with nonimmunogenic small peptides and vasoactive amines. Limited local toxicity occurs with stings; systemic reactions to venoms are mediated by IgE antibodies and can be prevented by immunization with the appropriate venom. Skin testing with venoms detects the sensitized state, and a positive test predicts a 50 to 60% risk of an allergic response to a future sting. Because considerable cross-reactivity exists between vespid venom allergens, choice of correct venom(s) for immunotherapy will not always be indicated by skin-testing with whole, unfractionated venom. Further efforts at skin testing with individual venom antigens may help to resolve problems regarding choice of venoms for immunotherapy.

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Allergens of Hymenopteran Venoms

Abstract

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