Abstract
Venoms of the Hymenoptera are mixtures of several antigens with nonimmunogenic small peptides and vasoactive amines. Limited local toxicity occurs with stings; systemic reactions to venoms are mediated by IgE antibodies and can be prevented by immunization with the appropriate venom. Skin testing with venoms detects the sensitized state, and a positive test predicts a 50 to 60% risk of an allergic response to a future sting. Because considerable cross-reactivity exists between vespid venom allergens, choice of correct venom(s) for immunotherapy will not always be indicated by skin-testing with whole, unfractionated venom. Further efforts at skin testing with individual venom antigens may help to resolve problems regarding choice of venoms for immunotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 137-148 |
| Number of pages | 12 |
| Journal | Clinical Reviews in Allergy |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1987 |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
- Medicine(all)
Cite this
Allergens of Hymenopteran Venoms. / King, T. P.; Valentine, Martin D.
In: Clinical Reviews in Allergy, Vol. 5, No. 2, 05.1987, p. 137-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Allergens of Hymenopteran Venoms
AU - King, T. P.
AU - Valentine, Martin D.
PY - 1987/5
Y1 - 1987/5
N2 - Venoms of the Hymenoptera are mixtures of several antigens with nonimmunogenic small peptides and vasoactive amines. Limited local toxicity occurs with stings; systemic reactions to venoms are mediated by IgE antibodies and can be prevented by immunization with the appropriate venom. Skin testing with venoms detects the sensitized state, and a positive test predicts a 50 to 60% risk of an allergic response to a future sting. Because considerable cross-reactivity exists between vespid venom allergens, choice of correct venom(s) for immunotherapy will not always be indicated by skin-testing with whole, unfractionated venom. Further efforts at skin testing with individual venom antigens may help to resolve problems regarding choice of venoms for immunotherapy.
AB - Venoms of the Hymenoptera are mixtures of several antigens with nonimmunogenic small peptides and vasoactive amines. Limited local toxicity occurs with stings; systemic reactions to venoms are mediated by IgE antibodies and can be prevented by immunization with the appropriate venom. Skin testing with venoms detects the sensitized state, and a positive test predicts a 50 to 60% risk of an allergic response to a future sting. Because considerable cross-reactivity exists between vespid venom allergens, choice of correct venom(s) for immunotherapy will not always be indicated by skin-testing with whole, unfractionated venom. Further efforts at skin testing with individual venom antigens may help to resolve problems regarding choice of venoms for immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=0023333080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023333080&partnerID=8YFLogxK
U2 - 10.1007/BF02991203
DO - 10.1007/BF02991203
M3 - Article
C2 - 3581009
AN - SCOPUS:0023333080
VL - 5
SP - 137
EP - 148
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
SN - 1080-0549
IS - 2
ER -