Allergen-specific immunotherapy

Harold S. Nelson, Philip S. Norman

Research output: Contribution to journalArticle

Abstract

Specific immunotherapy was introduced for the treatment of grass pollen-induced hay fever in 1911. The treatment was soon extended to other pollens as well as perennial allergens, and to the treatment of bronchial asthma. Definitive studies of its efficacy for both rhinitis and asthma came only many decades later. Understanding gradually emerged of the underlying immunologic mechanisms that include the generation of regulatory T lymphocytes, immune deviation from allergen-specific Th2 to Th1 responses, and a shift in allergen-specific antibody production from immunoglobulin (Ig) E to IgG4. Along with understanding of the immune basis came an appreciation that immunotherapy modifies allergic disease expression, producing protection against disease progression and symptomatic improvement that persists for years after the treatment is discontinued. Recent new directions for immunotherapy include sublingual administration of inhalant allergens and use of the oral route to treat food allergy.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalChemical Immunology and Allergy
Volume100
DOIs
StatePublished - 2014

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Immunologic Desensitization
Allergens
Immunotherapy
Pollen
Asthma
Sublingual Administration
Seasonal Allergic Rhinitis
Food Hypersensitivity
Regulatory T-Lymphocytes
Therapeutics
Rhinitis
Poaceae
Immunoglobulin E
Antibody Formation
Disease Progression
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

Cite this

Allergen-specific immunotherapy. / Nelson, Harold S.; Norman, Philip S.

In: Chemical Immunology and Allergy, Vol. 100, 2014, p. 333-338.

Research output: Contribution to journalArticle

Nelson, Harold S. ; Norman, Philip S. / Allergen-specific immunotherapy. In: Chemical Immunology and Allergy. 2014 ; Vol. 100. pp. 333-338.
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