Allergen-induced sensory neuroplasticity in airways

Bradley J. Undem, Dawn D. Hunter, Mark Liu, Mary Haak-Frendscho, Angela Oakragly, Axel Fischer

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigates the influence of allergic inflammation in airway sensory innervation. We conclude that allergic inflammation in the guinea pig leads to both an increase in excitability, as manifested by an increase in the mechanical sensitivity of the airway nerve endings, and an induction of substance P production in airway sensory neurons. The data are consistent with the hypothesis that the induction of substance P occurs in fast conducting nodose sensory neurons that were previously devoid of this neuropeptide. Thus, allergen challenge is associated with a phenotypic change in the airway tachykinergic innervation. We also provide evidence that nerve growth factor is a potentially important mediator for these effects, and that it is elevated in the bronchoalveolar ravage of asthmatic subjects.

Original languageEnglish (US)
Pages (from-to)150-153
Number of pages4
JournalInternational archives of allergy and immunology
Volume118
Issue number2-4
DOIs
StatePublished - Jan 1 1999

Keywords

  • Bronchus
  • Neuropeptide
  • Sensory nerve
  • Substance P
  • Vagus nerve

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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