Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas

James D. Brooks, G. Steven Bova, William B. Isaacs

Research output: Contribution to journalArticle

Abstract

Inactivation of the retinoblastoma (Rb) gene has been implicated in the genesis and progression of a number of tumor types, including prostatic adenocarcinomas. We have analyzed a series of 46 surgically‐resected human prostatic adenocarcinomas for allelic loss of the Rb gene with PCR amplification of a highly polymorphic region of the gene. 41 of 46 tumors (89%) were informative and 11 of these (27%) had lost one Rb allele. The relative frequency of this occurrence suggests that inactivation of the retinoblastoma gene may be an important event in prostate carcinogenesis.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalThe Prostate
Volume26
Issue number1
DOIs
StatePublished - Jan 1995

Keywords

  • allelic loss
  • prostate cancer
  • retinoblastoma gene

ASJC Scopus subject areas

  • Oncology
  • Urology

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