@article{6533bc38a13b45d4bad510cc4758fc93,
title = "Allele-specific expression reveals interactions between genetic variation and environment",
abstract = "Identifying interactions between genetics and the environment (GxE) remains challenging. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on associations between environmental variables and allele-specific expression. Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared with only four using standard GxE interaction testing. EAGLE provides new opportunities for researchers to identify GxE interactions using functional genomic data.",
author = "Knowles, {David A.} and Davis, {Joe R.} and Hilary Edgington and Anil Raj and Fav{\'e}, {Marie Julie} and Xiaowei Zhu and Potash, {James B.} and Weissman, {Myrna M.} and Jianxin Shi and Levinson, {Douglas F.} and Philip Awadalla and Sara Mostafavi and Montgomery, {Stephen B.} and Alexis Battle",
note = "Funding Information: We would like to thank J. Leek for helpful comments and S. Kersten for providing the graphic from which the PPARα network figure was adapted. D.A.K. is supported by NIH U54CA149145. M.-J.F. is supported by a CIHR Neuroinflammation fellowship. P.A. is supported by the Ontario Ministry of Research and Innovation. A.B. and S.B.M. are supported by NIH R01MH101814 and NIH R01HG008150. A.B. is supported by the Searle Scholars Program, NIH R01MH101820, NIH 1R01MH109905-01, and NIH 1R01GM120167-010. S.B.M. is supported by the Edward Mallinckrodt Jr. Foundation. Publisher Copyright: {\textcopyright} 2017 Nature America, Inc., part of Springer Nature. All rights reserved.",
year = "2017",
month = jun,
day = "29",
doi = "10.1038/nmeth.4298",
language = "English (US)",
volume = "14",
pages = "699--702",
journal = "PLoS Medicine",
issn = "1549-1277",
publisher = "Nature Publishing Group",
number = "7",
}