Abstract
The end result of the antigen-processing pathway is the display of peptide-bound major histocompatibility complex I (pMHC I) molecules. The pMHC I molecules are expressed on the cell surface where they can be surveyed by CD8+ T cells for abnormal proteins. MHC I molecules present a large repertoire of peptides that fit perfectly in their binding grooves and represent the otherwise hidden intracellular contents. Many peptides originate as defective ribosomal products in the cytoplasm. In a stepwise manner, the antigen-processing pathway generates and protects the proteolytic intermediates until they yield the final peptides that can fit the MHC I in the endoplasmic reticulum.
Original language | English (US) |
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Pages (from-to) | 31-41 |
Number of pages | 11 |
Journal | Immunological reviews |
Volume | 207 |
DOIs | |
State | Published - Oct 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology