All the peptides that fit: The beginning, the middle, and the end of the MHC class I antigen-processing pathway

Nilabh Shastri, Sylvain Cardinaud, Susan R. Schwab, Thomas Serwold, Jun Kunisawa

Research output: Contribution to journalReview articlepeer-review

Abstract

The end result of the antigen-processing pathway is the display of peptide-bound major histocompatibility complex I (pMHC I) molecules. The pMHC I molecules are expressed on the cell surface where they can be surveyed by CD8+ T cells for abnormal proteins. MHC I molecules present a large repertoire of peptides that fit perfectly in their binding grooves and represent the otherwise hidden intracellular contents. Many peptides originate as defective ribosomal products in the cytoplasm. In a stepwise manner, the antigen-processing pathway generates and protects the proteolytic intermediates until they yield the final peptides that can fit the MHC I in the endoplasmic reticulum.

Original languageEnglish (US)
Pages (from-to)31-41
Number of pages11
JournalImmunological reviews
Volume207
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'All the peptides that fit: The beginning, the middle, and the end of the MHC class I antigen-processing pathway'. Together they form a unique fingerprint.

Cite this