All tangled up: How cells direct, manage and exploit topoisomerase function

Seychelle M. Vos, Elsa M. Tretter, Bryan H. Schmidt, James M Berger

Research output: Contribution to journalArticle

Abstract

Topoisomerases are complex molecular machines that modulate DNA topology to maintain chromosome superstructure and integrity. Although capable of stand-alone activity in vitro, topoisomerases are frequently linked to larger pathways and systems that resolve specific DNA superstructures and intermediates arising from cellular processes such as DNA repair, transcription, replication and chromosome compaction. Topoisomerase activity is indispensible to cells, but requires the transient breakage of DNA strands. This property has been exploited, often for significant clinical benefit, by various exogenous agents that interfere with cell proliferation. Despite decades of study, surprising findings involving topoisomerases continue to emerge with respect to their cellular function, regulation and utility as therapeutic targets.

Original languageEnglish (US)
Pages (from-to)827-841
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume12
Issue number12
DOIs
StatePublished - Dec 2011
Externally publishedYes

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DNA
Chromosomes
DNA Repair
Cell Proliferation
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

All tangled up : How cells direct, manage and exploit topoisomerase function. / Vos, Seychelle M.; Tretter, Elsa M.; Schmidt, Bryan H.; Berger, James M.

In: Nature Reviews Molecular Cell Biology, Vol. 12, No. 12, 12.2011, p. 827-841.

Research output: Contribution to journalArticle

Vos, Seychelle M. ; Tretter, Elsa M. ; Schmidt, Bryan H. ; Berger, James M. / All tangled up : How cells direct, manage and exploit topoisomerase function. In: Nature Reviews Molecular Cell Biology. 2011 ; Vol. 12, No. 12. pp. 827-841.
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