All monocyte antigens are not expressed on renal endothelium

W. M. Baldwin, F. H J Claas, L. C. Paul, T. A. Springer, G. F. Hendriks, L. A. van Es, J. J. van Rood

Research output: Contribution to journalArticlepeer-review

Abstract

Recently a tissue restricted antigen system, which is expressed on endothelial cells and monocytes (E-M antigens) but not lymphocytes, has been associated with kidney graft rejection. In screening sera from recipients of kidney, bone marrow or skin grafts for possible reactivity with endothelial cell antigens, we have found that all (13 of 13) endothelial reactive sera also reacted with monocytes, but that many (21 of 34) monocyte reactive did not react with endothelial cells. Additionally, one well-defined monoclonal antibody (M1/70), which was cytotoxic for human monocytes, neither stained renal endothelium nor was absorbed by renal endothelium when perfused through a human kidney. Thus, not all monocyte antigens appear to be expressed in high concentrations on renal vascular endothelium. This may explain why monocyte reactive antibodies do not always correlate with kidney graft rejection.

Original languageEnglish (US)
Pages (from-to)254-259
Number of pages6
JournalTissue Antigens
Volume21
Issue number3
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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