Alignment of sound localization cues in the nucleus of the brachium of the inferior colliculus

Sean J. Slee, Eric D. Young

Research output: Contribution to journalArticle

Abstract

Accurate sound localization is based on three acoustic cues (interaural time and intensity difference and spectral cues from directional filtering by the pinna). In natural listening conditions, every spatial position of a sound source provides a unique combination of these three cues in "natural alignment." Although neurons in the central nucleus (ICC) of the inferior colliculus (IC) are sensitive to multiple cues, they do not favor their natural spatial alignment. We tested for sensitivity to cue alignment in the nucleus of the brachium of the IC (BIN) in unanesthetized marmoset monkeys. The BIN receives its predominant auditory input from ICC and projects to the topographic auditory space map in the superior colliculus. Sound localization cues measured in each monkey were used to synthesize broadband stimuli with aligned and misaligned cues; spike responses to these stimuli were recorded in the BIN. We computed mutual information (MI) between the set of spike rates and the stimuli containing either aligned or misaligned cues. The results can be summarized as follows: 1) BIN neurons encode more information about auditory space when cues are aligned compared with misaligned. 2) Significantly more units prefer aligned cues in the BIN than in ICC. 3) An additive model based on summing the responses to stimuli with the localization cues varying individually accurately predicts the alignment preference with all cues varying. Overall, the results suggest that the BIN is the first site in the ascending mammalian auditory system that is tuned to natural combinations of sound localization cues.

Original languageEnglish (US)
Pages (from-to)2624-2633
Number of pages10
JournalJournal of Neurophysiology
Volume111
Issue number12
DOIs
StatePublished - Jun 15 2014
Externally publishedYes

Fingerprint

Sound Localization
Inferior Colliculi
Cues
Arm
Haplorhini
Neurons
Callithrix
Superior Colliculi
Acoustics

Keywords

  • Brachium of inferior colliculus
  • Cue alignment
  • Inferior colliculus
  • Marmoset monkey
  • Sound localization

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Medicine(all)

Cite this

Alignment of sound localization cues in the nucleus of the brachium of the inferior colliculus. / Slee, Sean J.; Young, Eric D.

In: Journal of Neurophysiology, Vol. 111, No. 12, 15.06.2014, p. 2624-2633.

Research output: Contribution to journalArticle

Slee, Sean J. ; Young, Eric D. / Alignment of sound localization cues in the nucleus of the brachium of the inferior colliculus. In: Journal of Neurophysiology. 2014 ; Vol. 111, No. 12. pp. 2624-2633.
@article{95ab210b7a8a46f69c8db107671fbb5a,
title = "Alignment of sound localization cues in the nucleus of the brachium of the inferior colliculus",
abstract = "Accurate sound localization is based on three acoustic cues (interaural time and intensity difference and spectral cues from directional filtering by the pinna). In natural listening conditions, every spatial position of a sound source provides a unique combination of these three cues in {"}natural alignment.{"} Although neurons in the central nucleus (ICC) of the inferior colliculus (IC) are sensitive to multiple cues, they do not favor their natural spatial alignment. We tested for sensitivity to cue alignment in the nucleus of the brachium of the IC (BIN) in unanesthetized marmoset monkeys. The BIN receives its predominant auditory input from ICC and projects to the topographic auditory space map in the superior colliculus. Sound localization cues measured in each monkey were used to synthesize broadband stimuli with aligned and misaligned cues; spike responses to these stimuli were recorded in the BIN. We computed mutual information (MI) between the set of spike rates and the stimuli containing either aligned or misaligned cues. The results can be summarized as follows: 1) BIN neurons encode more information about auditory space when cues are aligned compared with misaligned. 2) Significantly more units prefer aligned cues in the BIN than in ICC. 3) An additive model based on summing the responses to stimuli with the localization cues varying individually accurately predicts the alignment preference with all cues varying. Overall, the results suggest that the BIN is the first site in the ascending mammalian auditory system that is tuned to natural combinations of sound localization cues.",
keywords = "Brachium of inferior colliculus, Cue alignment, Inferior colliculus, Marmoset monkey, Sound localization",
author = "Slee, {Sean J.} and Young, {Eric D.}",
year = "2014",
month = "6",
day = "15",
doi = "10.1152/jn.00885.2013",
language = "English (US)",
volume = "111",
pages = "2624--2633",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "12",

}

TY - JOUR

T1 - Alignment of sound localization cues in the nucleus of the brachium of the inferior colliculus

AU - Slee, Sean J.

AU - Young, Eric D.

PY - 2014/6/15

Y1 - 2014/6/15

N2 - Accurate sound localization is based on three acoustic cues (interaural time and intensity difference and spectral cues from directional filtering by the pinna). In natural listening conditions, every spatial position of a sound source provides a unique combination of these three cues in "natural alignment." Although neurons in the central nucleus (ICC) of the inferior colliculus (IC) are sensitive to multiple cues, they do not favor their natural spatial alignment. We tested for sensitivity to cue alignment in the nucleus of the brachium of the IC (BIN) in unanesthetized marmoset monkeys. The BIN receives its predominant auditory input from ICC and projects to the topographic auditory space map in the superior colliculus. Sound localization cues measured in each monkey were used to synthesize broadband stimuli with aligned and misaligned cues; spike responses to these stimuli were recorded in the BIN. We computed mutual information (MI) between the set of spike rates and the stimuli containing either aligned or misaligned cues. The results can be summarized as follows: 1) BIN neurons encode more information about auditory space when cues are aligned compared with misaligned. 2) Significantly more units prefer aligned cues in the BIN than in ICC. 3) An additive model based on summing the responses to stimuli with the localization cues varying individually accurately predicts the alignment preference with all cues varying. Overall, the results suggest that the BIN is the first site in the ascending mammalian auditory system that is tuned to natural combinations of sound localization cues.

AB - Accurate sound localization is based on three acoustic cues (interaural time and intensity difference and spectral cues from directional filtering by the pinna). In natural listening conditions, every spatial position of a sound source provides a unique combination of these three cues in "natural alignment." Although neurons in the central nucleus (ICC) of the inferior colliculus (IC) are sensitive to multiple cues, they do not favor their natural spatial alignment. We tested for sensitivity to cue alignment in the nucleus of the brachium of the IC (BIN) in unanesthetized marmoset monkeys. The BIN receives its predominant auditory input from ICC and projects to the topographic auditory space map in the superior colliculus. Sound localization cues measured in each monkey were used to synthesize broadband stimuli with aligned and misaligned cues; spike responses to these stimuli were recorded in the BIN. We computed mutual information (MI) between the set of spike rates and the stimuli containing either aligned or misaligned cues. The results can be summarized as follows: 1) BIN neurons encode more information about auditory space when cues are aligned compared with misaligned. 2) Significantly more units prefer aligned cues in the BIN than in ICC. 3) An additive model based on summing the responses to stimuli with the localization cues varying individually accurately predicts the alignment preference with all cues varying. Overall, the results suggest that the BIN is the first site in the ascending mammalian auditory system that is tuned to natural combinations of sound localization cues.

KW - Brachium of inferior colliculus

KW - Cue alignment

KW - Inferior colliculus

KW - Marmoset monkey

KW - Sound localization

UR - http://www.scopus.com/inward/record.url?scp=84902770592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902770592&partnerID=8YFLogxK

U2 - 10.1152/jn.00885.2013

DO - 10.1152/jn.00885.2013

M3 - Article

C2 - 24671535

AN - SCOPUS:84902770592

VL - 111

SP - 2624

EP - 2633

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 12

ER -