TY - JOUR
T1 - Aldosterone and aldosterone
T2 - Renin ratio associations with insulin resistance and blood pressure in African Americans
AU - Huan, Yonghong
AU - DeLoach, Stephanie
AU - Keith, Scott W.
AU - Goodfriend, Theodore L.
AU - Falkner, Bonita
N1 - Funding Information:
Financial support: This work was supported by a grant from the Pennsylvania Department of Public Health and in part by grants from the Research Service, Department of Veterans Affairs and the National Institutes of Health . The Pennsylvania Department of Public Health disclaims responsibility for any analyses, interpretations, or conclusions.
PY - 2012/1
Y1 - 2012/1
N2 - African Americans have more hypertension and hypertension-related morbidity than whites. Aldosterone, in presence of a high salt intake, contributes to hypertension and tissue injury. Inappropriately elevated aldosterone levels could explain this racial disparity. Our study was conducted to determine if aldosterone is associated with elevated blood pressure (BP) or insulin resistance, independent of obesity. A study was conducted on 483 young adult African Americans without cardiovascular or renal disease. Measurements included anthropometrics, BP, lipids, glucose, insulin, aldosterone, and renin. Urine sodium and potassium estimated sodium intake. The cohort was stratified by tertiles of aldosterone and tertiles of aldosterone/renin ratio (ARR). Average urine sodium/potassium ratio was >3.0 in all groups. Insulin resistance, estimated by homeostasis model, was lowest in the low aldosterone group (geometric mean 1.5 [0.6, 2.2]) compared with the high aldosterone group (1.7 [0.9, 2.7], P <.01). Adjusted analyses detected a significant association of aldosterone with insulin resistance, independent of other variables. BP was significantly higher in the high ARR group compared with low and mid ARR groups (P <.01). The significant association of ARR with BP with high dietary sodium suggests that insufficiently suppressed aldosterone may contribute to BP sensitivity to sodium in African Americans.
AB - African Americans have more hypertension and hypertension-related morbidity than whites. Aldosterone, in presence of a high salt intake, contributes to hypertension and tissue injury. Inappropriately elevated aldosterone levels could explain this racial disparity. Our study was conducted to determine if aldosterone is associated with elevated blood pressure (BP) or insulin resistance, independent of obesity. A study was conducted on 483 young adult African Americans without cardiovascular or renal disease. Measurements included anthropometrics, BP, lipids, glucose, insulin, aldosterone, and renin. Urine sodium and potassium estimated sodium intake. The cohort was stratified by tertiles of aldosterone and tertiles of aldosterone/renin ratio (ARR). Average urine sodium/potassium ratio was >3.0 in all groups. Insulin resistance, estimated by homeostasis model, was lowest in the low aldosterone group (geometric mean 1.5 [0.6, 2.2]) compared with the high aldosterone group (1.7 [0.9, 2.7], P <.01). Adjusted analyses detected a significant association of aldosterone with insulin resistance, independent of other variables. BP was significantly higher in the high ARR group compared with low and mid ARR groups (P <.01). The significant association of ARR with BP with high dietary sodium suggests that insufficiently suppressed aldosterone may contribute to BP sensitivity to sodium in African Americans.
KW - African Americans
KW - Aldosterone
KW - blood pressure
KW - insulin resistance
KW - renin
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U2 - 10.1016/j.jash.2011.09.005
DO - 10.1016/j.jash.2011.09.005
M3 - Article
C2 - 22024666
AN - SCOPUS:84855840698
SN - 1933-1711
VL - 6
SP - 56
EP - 65
JO - Journal of the American Society of Hypertension
JF - Journal of the American Society of Hypertension
IS - 1
ER -