Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease

Huaibin Cai, Guoxiang Liu, Lixin Sun, Jinhui Ding

    Research output: Contribution to journalReview article

    Abstract

    A preferential dysfunction/loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) accounts for the main motor symptoms of Parkinson's disease (PD), the most common degenerative movement disorder. However, the neuronal loss is not stochastic, but rather displays regionally selectivity, indicating the existence of different DA subpopulations in the SNpc. To identify the underlying molecular determinants is thereby instrumental in understanding the pathophysiological mechanisms of PD-related neuron dysfunction/loss and offering new therapeutic targets. Recently, we have demonstrated that aldehyde dehydrogenase 1 (ALDH1A1) is one such molecular determinant that defines and protects an SNpc DA neuron subpopulation preferentially affected in PD. In this review, we provide further analysis and discussion on the roles of ALDH1A1 in the function and survival of SNpc DA neurons in both rodent and human brains. We also explore the feasibility of ALDH1A1 as a potential biomarker and therapeutic target for PD.

    Original languageEnglish (US)
    Article number27
    JournalTranslational Neurodegeneration
    Volume3
    Issue number1
    DOIs
    StatePublished - Dec 10 2014

    Keywords

    • Aging
    • Aldehyde dehydrogenase 1
    • Dopaminergic neuron
    • Neurodegeneration
    • Parkinson's disease
    • Substantia nigra pars compacta
    • α-synuclein

    ASJC Scopus subject areas

    • Clinical Neurology
    • Cognitive Neuroscience
    • Cellular and Molecular Neuroscience

    Fingerprint Dive into the research topics of 'Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease'. Together they form a unique fingerprint.

  • Cite this