Alcoholic liver disease: Roles of alcohol and malnutrition

Research output: Contribution to journalArticle

Abstract

A toxic effect of alcohol is the principal cause of the development of liver disease in alcoholism. Fatty infiltration of the liver is a consequence of ethanol metabolism due mainly to an increased synthesis and decreased degradation of fatty acids. Mechanisms that have been suggested for ethanol-induced hepatocellular necrosis include centrolobular hypoxia due to an increased oxygen requirement and intracellular accumulation of protein, fat, and water which results in increased cell size. Hepatocellular necrosis, however, may not be a necessary stage in the development of cirrhosis. Chronic ethanol administration increases hepatic collagen deposition, and acute and chronic ethanol administration inhibit liver cell regeneration. Increased humoral and cellular immunological activity to liver tissue and its components may contribute to the persistence of liver disease in the alcoholic. However, only a small proportion of alcoholics and baboons fed alcohol develop cirrhosis, suggesting that other factors, either genetic, environmental, or nutritional, play a role. Malnutrition is common in alcoholics. Liver disease is more common in some malnourished populations, and has been produced by nutrient deficiencies. Decreased dietary intake, as well as malabsorption and alterations in the metabolism of nutrients, are causes of nutrient deficiencies in alcoholism. Some of the effects of alcohol on the liver may be mediated by its actions on nutrient absorption and metabolism.

Original languageEnglish (US)
Pages (from-to)2709-2718
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume33
Issue number12
StatePublished - 1980

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Alcoholic Liver Diseases
liver diseases
alcohol abuse
Malnutrition
malnutrition
Ethanol
alcohols
Alcohols
Food
ethanol
Alcoholics
liver
Alcoholism
Liver Diseases
Liver
nutrient deficiencies
Fibrosis
Necrosis
metabolism
necrosis

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Alcoholic liver disease : Roles of alcohol and malnutrition. / Mezey, Esteban.

In: American Journal of Clinical Nutrition, Vol. 33, No. 12, 1980, p. 2709-2718.

Research output: Contribution to journalArticle

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