Alcoholic Hepatitis: Risk Factors, Pathogenesis, and Approach to Treatment

Apurva Yeluru, Jennifer A. Cuthbert, Lisa Casey, Mack C. Mitchell

Research output: Contribution to journalArticle

Abstract

Background: Alcoholic hepatitis (AH) is an inflammatory disorder of the liver characterized clinically by jaundice, hepatomegaly, and abdominal pain, and histologically by macrovesicular steatosis and necroinflammation. Methods: This clinical review will cover what is known about the pathogenesis, clinical presentation, current treatments, and novel therapies for AH. Results: The pathogenesis and treatment of AH remain areas of active research. Although abstinence is the cornerstone of therapy for all stages of alcoholic liver disease, corticosteroids have shown modest short-term benefits in treatment of severe AH. Conclusions: Improved understanding of the pathogenesis of AH has expanded the range of potential treatments for this devastating disease. Several novel therapies are also currently in various stages of testing through clinical trials.

Original languageEnglish (US)
Pages (from-to)246-255
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume40
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Fingerprint

Alcoholic Hepatitis
Liver
Adrenal Cortex Hormones
Testing
Therapeutics
Alcoholic Liver Diseases
Hepatomegaly
Jaundice
Abdominal Pain
Clinical Trials
Research

Keywords

  • Alcoholic Hepatitis
  • Alcoholic Liver Disease
  • Ethanol
  • Fatty Liver
  • Innate Immune Response

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Alcoholic Hepatitis : Risk Factors, Pathogenesis, and Approach to Treatment. / Yeluru, Apurva; Cuthbert, Jennifer A.; Casey, Lisa; Mitchell, Mack C.

In: Alcoholism: Clinical and Experimental Research, Vol. 40, No. 2, 01.02.2016, p. 246-255.

Research output: Contribution to journalArticle

Yeluru, Apurva ; Cuthbert, Jennifer A. ; Casey, Lisa ; Mitchell, Mack C. / Alcoholic Hepatitis : Risk Factors, Pathogenesis, and Approach to Treatment. In: Alcoholism: Clinical and Experimental Research. 2016 ; Vol. 40, No. 2. pp. 246-255.
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