Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility

Jasenka Demirovic, Azmi Nabulsi, Aaron R. Folsom, Myra A. Carpenter, Moyses Szklo, Paul D. Sorlie, Ralph W. Barnes

Research output: Contribution to journalArticle

Abstract

Background. Although much has been written in recent years about the relation between alcohol and atherosclerotic disease, controversy exists as to whether and how alcohol exerts an effect on atherosclerosis in different sites. Methods and Results. We tested the hypothesis that alcohol consumption is associated inversely with carotid atherosclerosis in a population sample of 45- to 64-year-old men and women who participated in the Atherosclerosis Risk in Communities (ARIC) Study and were free of cardiovascular disease at a baseline examination in 1987 to 1989. B-mode ultrasonography was used to determine carotid artery intimal-medial wall thickness and distensibility as indices of the degree of atherosclerosis. The level of alcohol consumption in the ARIC sample was generally low. Age-adjusted mean values of alcohol consumed (grams per week) were 72.0 for white and 74.3 for nonwhite men and 24.8 for white and 11.2 for nonwhite women. After adjustments for age, artery depth, education, body mass index, sport index, cigarette-years of smoking, low-density lipoprotein cholesterol, and diabetes mellitus, there was no significant cross-sectional association of reported current alcohol intake with either carotid artery wall thickness (among white and nonwhite men and nonwhite women) or distensibility (in any of the four sex-race groups). Among white women, the adjusted mean value of carotid artery wall thickness tended to be higher in light to moderate drinkers than in never or rare drinkers, but the difference across drinking status categories was of borderline statistical significance (P=.04) and may be of little biological importance. Conclusions. The ARIC Study found no material cross-sectional association between current alcohol intake and carotid atherosclerosis but provides an opportunity in the future to study atherosclerosis progression and incident events in relation to alcohol consumption in a large population sample of men and women.

Original languageEnglish (US)
Pages (from-to)2787-2793
Number of pages7
JournalCirculation
Volume88
Issue number6
StatePublished - Dec 1993

Fingerprint

Carotid Arteries
Alcohol Drinking
Atherosclerosis
Alcohols
Carotid Artery Diseases
Tunica Intima
LDL Cholesterol
Population
Drinking
Sports
Ultrasonography
Diabetes Mellitus
Body Mass Index
Cardiovascular Diseases
Arteries
Smoking
Education
Light

Keywords

  • Alcohol
  • Atherosclerosis
  • Ultrasonography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Demirovic, J., Nabulsi, A., Folsom, A. R., Carpenter, M. A., Szklo, M., Sorlie, P. D., & Barnes, R. W. (1993). Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility. Circulation, 88(6), 2787-2793.

Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility. / Demirovic, Jasenka; Nabulsi, Azmi; Folsom, Aaron R.; Carpenter, Myra A.; Szklo, Moyses; Sorlie, Paul D.; Barnes, Ralph W.

In: Circulation, Vol. 88, No. 6, 12.1993, p. 2787-2793.

Research output: Contribution to journalArticle

Demirovic, J, Nabulsi, A, Folsom, AR, Carpenter, MA, Szklo, M, Sorlie, PD & Barnes, RW 1993, 'Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility', Circulation, vol. 88, no. 6, pp. 2787-2793.
Demirovic J, Nabulsi A, Folsom AR, Carpenter MA, Szklo M, Sorlie PD et al. Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility. Circulation. 1993 Dec;88(6):2787-2793.
Demirovic, Jasenka ; Nabulsi, Azmi ; Folsom, Aaron R. ; Carpenter, Myra A. ; Szklo, Moyses ; Sorlie, Paul D. ; Barnes, Ralph W. / Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility. In: Circulation. 1993 ; Vol. 88, No. 6. pp. 2787-2793.
@article{e2949f7cc0c24c649993623507c0b02d,
title = "Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility",
abstract = "Background. Although much has been written in recent years about the relation between alcohol and atherosclerotic disease, controversy exists as to whether and how alcohol exerts an effect on atherosclerosis in different sites. Methods and Results. We tested the hypothesis that alcohol consumption is associated inversely with carotid atherosclerosis in a population sample of 45- to 64-year-old men and women who participated in the Atherosclerosis Risk in Communities (ARIC) Study and were free of cardiovascular disease at a baseline examination in 1987 to 1989. B-mode ultrasonography was used to determine carotid artery intimal-medial wall thickness and distensibility as indices of the degree of atherosclerosis. The level of alcohol consumption in the ARIC sample was generally low. Age-adjusted mean values of alcohol consumed (grams per week) were 72.0 for white and 74.3 for nonwhite men and 24.8 for white and 11.2 for nonwhite women. After adjustments for age, artery depth, education, body mass index, sport index, cigarette-years of smoking, low-density lipoprotein cholesterol, and diabetes mellitus, there was no significant cross-sectional association of reported current alcohol intake with either carotid artery wall thickness (among white and nonwhite men and nonwhite women) or distensibility (in any of the four sex-race groups). Among white women, the adjusted mean value of carotid artery wall thickness tended to be higher in light to moderate drinkers than in never or rare drinkers, but the difference across drinking status categories was of borderline statistical significance (P=.04) and may be of little biological importance. Conclusions. The ARIC Study found no material cross-sectional association between current alcohol intake and carotid atherosclerosis but provides an opportunity in the future to study atherosclerosis progression and incident events in relation to alcohol consumption in a large population sample of men and women.",
keywords = "Alcohol, Atherosclerosis, Ultrasonography",
author = "Jasenka Demirovic and Azmi Nabulsi and Folsom, {Aaron R.} and Carpenter, {Myra A.} and Moyses Szklo and Sorlie, {Paul D.} and Barnes, {Ralph W.}",
year = "1993",
month = "12",
language = "English (US)",
volume = "88",
pages = "2787--2793",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility

AU - Demirovic, Jasenka

AU - Nabulsi, Azmi

AU - Folsom, Aaron R.

AU - Carpenter, Myra A.

AU - Szklo, Moyses

AU - Sorlie, Paul D.

AU - Barnes, Ralph W.

PY - 1993/12

Y1 - 1993/12

N2 - Background. Although much has been written in recent years about the relation between alcohol and atherosclerotic disease, controversy exists as to whether and how alcohol exerts an effect on atherosclerosis in different sites. Methods and Results. We tested the hypothesis that alcohol consumption is associated inversely with carotid atherosclerosis in a population sample of 45- to 64-year-old men and women who participated in the Atherosclerosis Risk in Communities (ARIC) Study and were free of cardiovascular disease at a baseline examination in 1987 to 1989. B-mode ultrasonography was used to determine carotid artery intimal-medial wall thickness and distensibility as indices of the degree of atherosclerosis. The level of alcohol consumption in the ARIC sample was generally low. Age-adjusted mean values of alcohol consumed (grams per week) were 72.0 for white and 74.3 for nonwhite men and 24.8 for white and 11.2 for nonwhite women. After adjustments for age, artery depth, education, body mass index, sport index, cigarette-years of smoking, low-density lipoprotein cholesterol, and diabetes mellitus, there was no significant cross-sectional association of reported current alcohol intake with either carotid artery wall thickness (among white and nonwhite men and nonwhite women) or distensibility (in any of the four sex-race groups). Among white women, the adjusted mean value of carotid artery wall thickness tended to be higher in light to moderate drinkers than in never or rare drinkers, but the difference across drinking status categories was of borderline statistical significance (P=.04) and may be of little biological importance. Conclusions. The ARIC Study found no material cross-sectional association between current alcohol intake and carotid atherosclerosis but provides an opportunity in the future to study atherosclerosis progression and incident events in relation to alcohol consumption in a large population sample of men and women.

AB - Background. Although much has been written in recent years about the relation between alcohol and atherosclerotic disease, controversy exists as to whether and how alcohol exerts an effect on atherosclerosis in different sites. Methods and Results. We tested the hypothesis that alcohol consumption is associated inversely with carotid atherosclerosis in a population sample of 45- to 64-year-old men and women who participated in the Atherosclerosis Risk in Communities (ARIC) Study and were free of cardiovascular disease at a baseline examination in 1987 to 1989. B-mode ultrasonography was used to determine carotid artery intimal-medial wall thickness and distensibility as indices of the degree of atherosclerosis. The level of alcohol consumption in the ARIC sample was generally low. Age-adjusted mean values of alcohol consumed (grams per week) were 72.0 for white and 74.3 for nonwhite men and 24.8 for white and 11.2 for nonwhite women. After adjustments for age, artery depth, education, body mass index, sport index, cigarette-years of smoking, low-density lipoprotein cholesterol, and diabetes mellitus, there was no significant cross-sectional association of reported current alcohol intake with either carotid artery wall thickness (among white and nonwhite men and nonwhite women) or distensibility (in any of the four sex-race groups). Among white women, the adjusted mean value of carotid artery wall thickness tended to be higher in light to moderate drinkers than in never or rare drinkers, but the difference across drinking status categories was of borderline statistical significance (P=.04) and may be of little biological importance. Conclusions. The ARIC Study found no material cross-sectional association between current alcohol intake and carotid atherosclerosis but provides an opportunity in the future to study atherosclerosis progression and incident events in relation to alcohol consumption in a large population sample of men and women.

KW - Alcohol

KW - Atherosclerosis

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=0027492896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027492896&partnerID=8YFLogxK

M3 - Article

C2 - 8252692

AN - SCOPUS:0027492896

VL - 88

SP - 2787

EP - 2793

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 6

ER -