Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons

Marco Pahor, Jack M. Guralnik, Richard J. Havlik, Pierugo Carbonin, Marcel E. Salive, Luigi Ferrucci, Maria Chiara Corti, Charles H. Hennekens

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To assess whether low to moderate alcohol consumption decreases the risk of deep venous thrombosis and pulmonary embolism. DESIGN: Prospective cohort study. SETTING: Three communities of the Established Populations for Epidemiologic Studies of the Elderly. PARTICIPANTS: A total of 7959 persons aged 68 years or older. MEASUREMENTS: The incidence of deep venous thrombosis and pulmonary embolism was assessed by surveying hospital discharge diagnoses and deaths from 1985 through 1992. Those participants who estimated they used alcohol less than 1 time, on average, in the past month, less than 1 ounce per day, and 1 ounce or more per day were compared with those who reported no alcohol intake in the past year. Age, gender, race, body mass index, smoking, education, income, disability, cognitive function, arterial pressure, medication use, baseline chronic conditions, number of hospital admissions in past year, and occurrence of disease during follow-up were examined as possible confounders. RESULTS: During 48,038 person-years of follow-up, 155 events were observed (35 deep venous thromboses and 123 pulmonary emboli). Compared with non drinkers, after adjusting for potential confounding variables, the relative risks (95% confidence interval) for deep venous thrombosis and pulmonary embolism associated with increasing alcohol consumption levels were 0.7 (0.4-1.1), 0.6 (0.4-0.9), and 0.5 (0.2-1.1), respectively (P for trend = .004). The results were unchanged after stratifying on health status and disability. CONCLUSIONS: Low to moderate alcohol consumption is associated with a decreased risk of deep venous thrombosis and pulmonary embolism in older persons.

Original languageEnglish (US)
Pages (from-to)1030-1037
Number of pages8
JournalJournal of the American Geriatrics Society
Volume44
Issue number9
StatePublished - Sep 1996
Externally publishedYes

Fingerprint

Pulmonary Embolism
Venous Thrombosis
Alcohol Drinking
Alcohols
Confounding Factors (Epidemiology)
Embolism
Cognition
Health Status
Epidemiologic Studies
Arterial Pressure
Body Mass Index
Cohort Studies
Smoking
Prospective Studies
Confidence Intervals
Education
Lung
Incidence
Population

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Pahor, M., Guralnik, J. M., Havlik, R. J., Carbonin, P., Salive, M. E., Ferrucci, L., ... Hennekens, C. H. (1996). Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons. Journal of the American Geriatrics Society, 44(9), 1030-1037.

Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons. / Pahor, Marco; Guralnik, Jack M.; Havlik, Richard J.; Carbonin, Pierugo; Salive, Marcel E.; Ferrucci, Luigi; Corti, Maria Chiara; Hennekens, Charles H.

In: Journal of the American Geriatrics Society, Vol. 44, No. 9, 09.1996, p. 1030-1037.

Research output: Contribution to journalArticle

Pahor, M, Guralnik, JM, Havlik, RJ, Carbonin, P, Salive, ME, Ferrucci, L, Corti, MC & Hennekens, CH 1996, 'Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons', Journal of the American Geriatrics Society, vol. 44, no. 9, pp. 1030-1037.
Pahor M, Guralnik JM, Havlik RJ, Carbonin P, Salive ME, Ferrucci L et al. Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons. Journal of the American Geriatrics Society. 1996 Sep;44(9):1030-1037.
Pahor, Marco ; Guralnik, Jack M. ; Havlik, Richard J. ; Carbonin, Pierugo ; Salive, Marcel E. ; Ferrucci, Luigi ; Corti, Maria Chiara ; Hennekens, Charles H. / Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons. In: Journal of the American Geriatrics Society. 1996 ; Vol. 44, No. 9. pp. 1030-1037.
@article{fa0673b6cf0a4e6c858a694b399b1690,
title = "Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons",
abstract = "OBJECTIVES: To assess whether low to moderate alcohol consumption decreases the risk of deep venous thrombosis and pulmonary embolism. DESIGN: Prospective cohort study. SETTING: Three communities of the Established Populations for Epidemiologic Studies of the Elderly. PARTICIPANTS: A total of 7959 persons aged 68 years or older. MEASUREMENTS: The incidence of deep venous thrombosis and pulmonary embolism was assessed by surveying hospital discharge diagnoses and deaths from 1985 through 1992. Those participants who estimated they used alcohol less than 1 time, on average, in the past month, less than 1 ounce per day, and 1 ounce or more per day were compared with those who reported no alcohol intake in the past year. Age, gender, race, body mass index, smoking, education, income, disability, cognitive function, arterial pressure, medication use, baseline chronic conditions, number of hospital admissions in past year, and occurrence of disease during follow-up were examined as possible confounders. RESULTS: During 48,038 person-years of follow-up, 155 events were observed (35 deep venous thromboses and 123 pulmonary emboli). Compared with non drinkers, after adjusting for potential confounding variables, the relative risks (95{\%} confidence interval) for deep venous thrombosis and pulmonary embolism associated with increasing alcohol consumption levels were 0.7 (0.4-1.1), 0.6 (0.4-0.9), and 0.5 (0.2-1.1), respectively (P for trend = .004). The results were unchanged after stratifying on health status and disability. CONCLUSIONS: Low to moderate alcohol consumption is associated with a decreased risk of deep venous thrombosis and pulmonary embolism in older persons.",
author = "Marco Pahor and Guralnik, {Jack M.} and Havlik, {Richard J.} and Pierugo Carbonin and Salive, {Marcel E.} and Luigi Ferrucci and Corti, {Maria Chiara} and Hennekens, {Charles H.}",
year = "1996",
month = "9",
language = "English (US)",
volume = "44",
pages = "1030--1037",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Alcohol consumption and risk of deep venous thrombosis and pulmonary embolism in older persons

AU - Pahor, Marco

AU - Guralnik, Jack M.

AU - Havlik, Richard J.

AU - Carbonin, Pierugo

AU - Salive, Marcel E.

AU - Ferrucci, Luigi

AU - Corti, Maria Chiara

AU - Hennekens, Charles H.

PY - 1996/9

Y1 - 1996/9

N2 - OBJECTIVES: To assess whether low to moderate alcohol consumption decreases the risk of deep venous thrombosis and pulmonary embolism. DESIGN: Prospective cohort study. SETTING: Three communities of the Established Populations for Epidemiologic Studies of the Elderly. PARTICIPANTS: A total of 7959 persons aged 68 years or older. MEASUREMENTS: The incidence of deep venous thrombosis and pulmonary embolism was assessed by surveying hospital discharge diagnoses and deaths from 1985 through 1992. Those participants who estimated they used alcohol less than 1 time, on average, in the past month, less than 1 ounce per day, and 1 ounce or more per day were compared with those who reported no alcohol intake in the past year. Age, gender, race, body mass index, smoking, education, income, disability, cognitive function, arterial pressure, medication use, baseline chronic conditions, number of hospital admissions in past year, and occurrence of disease during follow-up were examined as possible confounders. RESULTS: During 48,038 person-years of follow-up, 155 events were observed (35 deep venous thromboses and 123 pulmonary emboli). Compared with non drinkers, after adjusting for potential confounding variables, the relative risks (95% confidence interval) for deep venous thrombosis and pulmonary embolism associated with increasing alcohol consumption levels were 0.7 (0.4-1.1), 0.6 (0.4-0.9), and 0.5 (0.2-1.1), respectively (P for trend = .004). The results were unchanged after stratifying on health status and disability. CONCLUSIONS: Low to moderate alcohol consumption is associated with a decreased risk of deep venous thrombosis and pulmonary embolism in older persons.

AB - OBJECTIVES: To assess whether low to moderate alcohol consumption decreases the risk of deep venous thrombosis and pulmonary embolism. DESIGN: Prospective cohort study. SETTING: Three communities of the Established Populations for Epidemiologic Studies of the Elderly. PARTICIPANTS: A total of 7959 persons aged 68 years or older. MEASUREMENTS: The incidence of deep venous thrombosis and pulmonary embolism was assessed by surveying hospital discharge diagnoses and deaths from 1985 through 1992. Those participants who estimated they used alcohol less than 1 time, on average, in the past month, less than 1 ounce per day, and 1 ounce or more per day were compared with those who reported no alcohol intake in the past year. Age, gender, race, body mass index, smoking, education, income, disability, cognitive function, arterial pressure, medication use, baseline chronic conditions, number of hospital admissions in past year, and occurrence of disease during follow-up were examined as possible confounders. RESULTS: During 48,038 person-years of follow-up, 155 events were observed (35 deep venous thromboses and 123 pulmonary emboli). Compared with non drinkers, after adjusting for potential confounding variables, the relative risks (95% confidence interval) for deep venous thrombosis and pulmonary embolism associated with increasing alcohol consumption levels were 0.7 (0.4-1.1), 0.6 (0.4-0.9), and 0.5 (0.2-1.1), respectively (P for trend = .004). The results were unchanged after stratifying on health status and disability. CONCLUSIONS: Low to moderate alcohol consumption is associated with a decreased risk of deep venous thrombosis and pulmonary embolism in older persons.

UR - http://www.scopus.com/inward/record.url?scp=0029811015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029811015&partnerID=8YFLogxK

M3 - Article

C2 - 8790226

AN - SCOPUS:0029811015

VL - 44

SP - 1030

EP - 1037

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 9

ER -