TY - JOUR
T1 - Alcohol consumption and premotor corpus callosum in older adults
AU - Kapogiannis, Dimitrios
AU - Kisser, Jason
AU - Davatzikos, Christos
AU - Ferrucci, Luigi
AU - Metter, Jeffrey
AU - Resnick, Susan M.
N1 - Funding Information:
This research was supported in part by the Intramural Research Program of the NIH/NIA and in part by N01-AG-3-2124. The study was conducted as part of official duty for U.S. Government employees DK, JK, JM, LF and SMR. The present manuscript underwent clearance for publication by NIA.
PY - 2012/10
Y1 - 2012/10
N2 - Heavy alcohol consumption is toxic to the brain, especially to the frontal white matter (WM), but whether lesser amounts of alcohol negatively impact the brain WM is unclear. In this study, we examined the relationship between self-reported alcohol consumption and regional WM and grey matter (GM) volume in fifty-six men and thirty-seven women (70. +. - 7. years) cognitively intact participants of the Baltimore Longitudinal Study of Aging (BLSA) with no history of alcohol abuse. We used regional analysis of volumes examined in normalized space (RAVENS) maps methodology for WM and GM segmentation and normalization followed by voxel based morphometry (VBM) implemented in SPM8 to examine the cross-sectional association between alcohol consumption and regional WM (and, separately, GM) volume controlling for age, sex, smoking, blood pressure and dietary thiamine intake. WM VBM revealed that in men, but not in women, higher alcohol consumption was associated with lower volume in premotor frontal corpus callosum. This finding suggests that even moderate amounts of alcohol may be detrimental to corpus callosum and white matter integrity.
AB - Heavy alcohol consumption is toxic to the brain, especially to the frontal white matter (WM), but whether lesser amounts of alcohol negatively impact the brain WM is unclear. In this study, we examined the relationship between self-reported alcohol consumption and regional WM and grey matter (GM) volume in fifty-six men and thirty-seven women (70. +. - 7. years) cognitively intact participants of the Baltimore Longitudinal Study of Aging (BLSA) with no history of alcohol abuse. We used regional analysis of volumes examined in normalized space (RAVENS) maps methodology for WM and GM segmentation and normalization followed by voxel based morphometry (VBM) implemented in SPM8 to examine the cross-sectional association between alcohol consumption and regional WM (and, separately, GM) volume controlling for age, sex, smoking, blood pressure and dietary thiamine intake. WM VBM revealed that in men, but not in women, higher alcohol consumption was associated with lower volume in premotor frontal corpus callosum. This finding suggests that even moderate amounts of alcohol may be detrimental to corpus callosum and white matter integrity.
KW - Alcohol
KW - Corpus callosum
KW - Premotor
KW - White matter
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U2 - 10.1016/j.euroneuro.2012.02.003
DO - 10.1016/j.euroneuro.2012.02.003
M3 - Article
C2 - 22401959
AN - SCOPUS:84865560828
SN - 0924-977X
VL - 22
SP - 704
EP - 710
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 10
ER -