TY - JOUR
T1 - Alcohol consumption and cardiac biomarkers
T2 - The atherosclerosis risk in communities (ARIC) study
AU - Lazo, Mariana
AU - Chen, Yuan
AU - McEvoy, John W.
AU - Ndumele, Chiadi
AU - Konety, Suma
AU - Ballantyne, Christie M.
AU - Sharrett, A. Richey
AU - Selvin, Elizabeth
N1 - Publisher Copyright:
© 2016 American Association for Clinical Chemistry.
PY - 2016/9
Y1 - 2016/9
N2 - BACKGROUND: The role of alcohol in the development of subclinical cardiovascular disease is unclear. We examined the association between alcohol consumption and markers of subclinical cardiac damage and wall stress. METHODS: We studied the cross-sectional and prospective associations of alcohol consumption with highsensitivity cardiac troponin T (hs-cTnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP) measured at 2 time points, 6 years apart (baseline, 1990-1992; follow-up, 1996-1998), in over 11000 participants of the Atherosclerosis Risk in Communities (ARIC) Study with no history of cardiovascular disease. Alcohol consumption was categorized as follows: never, former, current: 1, 2-7, 8-14, and 15 drinks/week. RESULTS: Compared to never drinkers, persons who consumed 2-7 drinks per week were less likely to have increased hs-cTnT (14 ng/L) at baseline (odds ratio 0.67, 95% CI, 0.46-0.96), and had a lower risk of incident increases in hs-cTnT at follow-up (relative risk0.70, 95% CI, 0.49-1.00). Conversely, there was a positive association between alcohol intake and NT-proBNP concentrations at baseline. Consumption of15 drinks/week was positively associated with incident increases in NT-proBNP (300 pg/mL) at the 6-year follow-up visit (relative risk 2.38, 95% CI, 1.43-3.96). CONCLUSIONS: In this community-based study of middle-aged adults without a history of cardiovascular disease, moderate drinking was associated with lower concentrations of hs-cTnT, a marker of chronic subclinical myocardial damage, and positively associated with NT-proBNP, a biomarker of cardiac wall stress. Our results suggest that the cardiac effects of alcohol are complex. Cardiac biomarkers may help improve our understanding of the full cardiovascular effects of alcohol consumption.
AB - BACKGROUND: The role of alcohol in the development of subclinical cardiovascular disease is unclear. We examined the association between alcohol consumption and markers of subclinical cardiac damage and wall stress. METHODS: We studied the cross-sectional and prospective associations of alcohol consumption with highsensitivity cardiac troponin T (hs-cTnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP) measured at 2 time points, 6 years apart (baseline, 1990-1992; follow-up, 1996-1998), in over 11000 participants of the Atherosclerosis Risk in Communities (ARIC) Study with no history of cardiovascular disease. Alcohol consumption was categorized as follows: never, former, current: 1, 2-7, 8-14, and 15 drinks/week. RESULTS: Compared to never drinkers, persons who consumed 2-7 drinks per week were less likely to have increased hs-cTnT (14 ng/L) at baseline (odds ratio 0.67, 95% CI, 0.46-0.96), and had a lower risk of incident increases in hs-cTnT at follow-up (relative risk0.70, 95% CI, 0.49-1.00). Conversely, there was a positive association between alcohol intake and NT-proBNP concentrations at baseline. Consumption of15 drinks/week was positively associated with incident increases in NT-proBNP (300 pg/mL) at the 6-year follow-up visit (relative risk 2.38, 95% CI, 1.43-3.96). CONCLUSIONS: In this community-based study of middle-aged adults without a history of cardiovascular disease, moderate drinking was associated with lower concentrations of hs-cTnT, a marker of chronic subclinical myocardial damage, and positively associated with NT-proBNP, a biomarker of cardiac wall stress. Our results suggest that the cardiac effects of alcohol are complex. Cardiac biomarkers may help improve our understanding of the full cardiovascular effects of alcohol consumption.
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U2 - 10.1373/clinchem.2016.255778
DO - 10.1373/clinchem.2016.255778
M3 - Article
C2 - 27440513
AN - SCOPUS:84985896490
SN - 0009-9147
VL - 62
SP - 1202
EP - 1210
JO - Clinical chemistry
JF - Clinical chemistry
IS - 9
ER -