TY - JOUR
T1 - Alcohol and Cannabis Use Disorder Symptom Severity, Conduct Disorder, and Callous-Unemotional Traits and Impairment in Expression Recognition
AU - Blair, Robert James R.
AU - Bashford-Largo, Johannah
AU - Zhang, Ru
AU - Mathur, Avantika
AU - Schwartz, Amanda
AU - Elowsky, Jaimie
AU - Tyler, Patrick
AU - Hammond, Christopher J.
AU - Filbey, Francesca M.
AU - Dobbertin, Matthew
AU - Bajaj, Sahil
AU - Blair, Karina S.
N1 - Funding Information:
Conflict of Interest: CH receives grant support from the National Institute on Drug Abuse, the American Academy of Child and Adolescent Psychiatry [AACAP Physician Scientist Career Development Award, K12DA000357], the National Network of Depression Centers, and the Armstrong Institute at Johns Hopkins Bayview and serves as a scientific advisor for the National Courts and Science Institute and as a subject matter expert for the Substance Abuse Mental Health Services Administration (SAMHSA).
Funding Information:
This work was supported by Boys Town National Research Hospital. RB was supported by the National Institutes of Health (P20GM130461) and the Rural Drug Addiction Research Center at the University of Nebraska-Lincoln. CH was supported by K12-DA000357 and R34-DA050292. The funders had no role in study design, data collection, data analysis, decision to publish, or manuscript preparation.
Publisher Copyright:
© Copyright © 2021 Blair, Bashford-Largo, Zhang, Mathur, Schwartz, Elowsky, Tyler, Hammond, Filbey, Dobbertin, Bajaj and Blair.
PY - 2021/9/20
Y1 - 2021/9/20
N2 - Background: Alcohol and cannabis are commonly used by adolescents in the United States. Both alcohol use disorder (AUD) and cannabis use disorder (CUD) have been associated with reduced emotion expression recognition ability. However, this work has primarily occurred in adults and has not considered neuro-cognitive risk factors associated with conduct problems that commonly co-occur with, and precede, substance use. Yet, conduct problems are also associated with reduced emotion expression recognition ability. The current study investigated the extent of negative association between AUD and CUD symptom severity and expression recognition ability over and above any association of expression recognition ability with conduct problems [conduct disorder (CD) diagnostic status]. Methods: In this study, 152 youths aged 12.5–18 years (56 female; 60 diagnosed with CD) completed a rapid presentation morphed intensity facial expression task to investigate the association between relative severity of AUD/CUD and expression recognition ability. Results: Cannabis use disorder identification test (CUDIT) scores were negatively associated with recognition accuracy for higher intensity (particularly sad and fearful) expressions while CD diagnostic status was independently negatively associated with recognition of sad expressions. Alcohol use disorder identification test (AUDIT) scores were not significantly associated with expression recognition ability. Conclusions: These data indicate that relative severity of CUD and CD diagnostic status are statistically independently associated with reduced expression recognition ability. On the basis of these data, we speculate that increased cannabis use during adolescence may exacerbate a neuro-cognitive risk factor for the emergence of aggression and antisocial behavior.
AB - Background: Alcohol and cannabis are commonly used by adolescents in the United States. Both alcohol use disorder (AUD) and cannabis use disorder (CUD) have been associated with reduced emotion expression recognition ability. However, this work has primarily occurred in adults and has not considered neuro-cognitive risk factors associated with conduct problems that commonly co-occur with, and precede, substance use. Yet, conduct problems are also associated with reduced emotion expression recognition ability. The current study investigated the extent of negative association between AUD and CUD symptom severity and expression recognition ability over and above any association of expression recognition ability with conduct problems [conduct disorder (CD) diagnostic status]. Methods: In this study, 152 youths aged 12.5–18 years (56 female; 60 diagnosed with CD) completed a rapid presentation morphed intensity facial expression task to investigate the association between relative severity of AUD/CUD and expression recognition ability. Results: Cannabis use disorder identification test (CUDIT) scores were negatively associated with recognition accuracy for higher intensity (particularly sad and fearful) expressions while CD diagnostic status was independently negatively associated with recognition of sad expressions. Alcohol use disorder identification test (AUDIT) scores were not significantly associated with expression recognition ability. Conclusions: These data indicate that relative severity of CUD and CD diagnostic status are statistically independently associated with reduced expression recognition ability. On the basis of these data, we speculate that increased cannabis use during adolescence may exacerbate a neuro-cognitive risk factor for the emergence of aggression and antisocial behavior.
KW - alcohol use disorder
KW - callous-unemotional traits
KW - cannabis use disorder
KW - conduct disorder
KW - expression recognition
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UR - http://www.scopus.com/inward/citedby.url?scp=85116479347&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2021.714189
DO - 10.3389/fpsyt.2021.714189
M3 - Article
C2 - 34616316
AN - SCOPUS:85116479347
SN - 1664-0640
VL - 12
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
M1 - 714189
ER -