Alcohol and breast cancer mortality in a cohort study

M. G. Jain, R. G. Ferrence, J. T. Rehm, S. J. Bondy, T. E. Rohan, M. J. Ashley, Joanna E Cohen, A. B. Miller

Research output: Contribution to journalArticle

Abstract

Available epidemiological evidence indicates that alcohol intake is associated with a higher risk of developing breast cancer. Plausible biological pathways include its effect on levels of estrogens, cell membrane integrity and cell-to-cell communication, inhibition of DNA repair, and congener effect. The present study evaluated the impact of alcohol on mortality from breast cancer, an area with relatively few studies in the literature· The subjects were participants in a Canadian prospective cohort study, the National Breast Screening Study (NBSS). Women were enrolled in the cohort from 1980 to 1985 to evaluate the efficacy of mammographic screening. Information on usual diet and alcohol intake at enrolment and other epidemiological variables was collected by means of a mailed, self-administered questionnaire. Mortality from breast cancer during follow-up to 31 December, 1993 was ascertained by record linkage to the Canadian Mortality Data Base maintained by Statistics Canada. During the follow-up period of 1980-1993 (average 10.3 years), 223 deaths from breast cancer were identified for this analysis. The hazard ratios for the risk of death from breast cancer increased with intakes of total alcohol of 10-20 g/day (1.039, 1.009-1.071) and > 20 g/day (1.063, 1.029-1.098. This increase was contributed largely by the intake of wine, a 15% increase in risk at intakes higher than 10 g/day of alcohol from wine. Alcohol from spirits was associated with a small decrease in risk of death (hazard ratio at 10 g/day, 0.945, 0.915-0.976). The effect of alcohol from beer was not significant in the two categories studied. Although our results were statistically significant, the magnitude of the change in risk was small.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalBreast Cancer Research and Treatment
Volume64
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Cohort Studies
Alcohols
Breast Neoplasms
Mortality
Wine
Cell Communication
DNA Repair
Canada
Estrogens
Breast
Odds Ratio
Cell Membrane
Databases
Prospective Studies
Diet

Keywords

  • Alcohol
  • Breast cancer
  • Cohort
  • Women

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Jain, M. G., Ferrence, R. G., Rehm, J. T., Bondy, S. J., Rohan, T. E., Ashley, M. J., ... Miller, A. B. (2000). Alcohol and breast cancer mortality in a cohort study. Breast Cancer Research and Treatment, 64(2), 201-209. https://doi.org/10.1023/A:1006402323445

Alcohol and breast cancer mortality in a cohort study. / Jain, M. G.; Ferrence, R. G.; Rehm, J. T.; Bondy, S. J.; Rohan, T. E.; Ashley, M. J.; Cohen, Joanna E; Miller, A. B.

In: Breast Cancer Research and Treatment, Vol. 64, No. 2, 2000, p. 201-209.

Research output: Contribution to journalArticle

Jain, MG, Ferrence, RG, Rehm, JT, Bondy, SJ, Rohan, TE, Ashley, MJ, Cohen, JE & Miller, AB 2000, 'Alcohol and breast cancer mortality in a cohort study', Breast Cancer Research and Treatment, vol. 64, no. 2, pp. 201-209. https://doi.org/10.1023/A:1006402323445
Jain MG, Ferrence RG, Rehm JT, Bondy SJ, Rohan TE, Ashley MJ et al. Alcohol and breast cancer mortality in a cohort study. Breast Cancer Research and Treatment. 2000;64(2):201-209. https://doi.org/10.1023/A:1006402323445
Jain, M. G. ; Ferrence, R. G. ; Rehm, J. T. ; Bondy, S. J. ; Rohan, T. E. ; Ashley, M. J. ; Cohen, Joanna E ; Miller, A. B. / Alcohol and breast cancer mortality in a cohort study. In: Breast Cancer Research and Treatment. 2000 ; Vol. 64, No. 2. pp. 201-209.
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