Albinterferon α-2b: A genetic fusion protein for the treatment of chronic hepatitis C

G. Mani Subramanian, Michele Fiscella, Araba Lamousé-Smith, Stefan Zeuzem, John G. McHutchison

Research output: Contribution to journalReview article

Abstract

Treatment regimens based on the use of interferon-α (IFN-α) remain the cornerstone of therapy for chronic hepatitis C virus infection, which affects nearly 170 million people worldwide. Treatment options include unmodified IFN-α given three times weekly or pegylated IFNs given once weekly. The albumin-fusion platform takes advantage of the long half-life of human albumin to provide a new treatment approach that allows the dosing frequency of IFN-α to be reduced in individuals with chronic hepatitis C. Albinterferon α-2b (alb-IFN), a recombinant polypeptide composed of IFN-α2b genetically fused to human albumin, has an extended half-life and early evidence indicates that it is efficacious and well tolerated. Pharmacodynamic modeling supports treatment with alb-IFN at 2- or 4-week intervals. Phase 3 registration trials are in progress. The albumin-fusion platform is currently being applied to other important bioactive peptides with short half-lives. These fusion proteins, which are at present in different phases of clinical development, might lead to improved therapies across a broad range of diseases.

Original languageEnglish (US)
Pages (from-to)1411-1419
Number of pages9
JournalNature biotechnology
Volume25
Issue number12
DOIs
StatePublished - Dec 1 2007

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ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

Cite this

Subramanian, G. M., Fiscella, M., Lamousé-Smith, A., Zeuzem, S., & McHutchison, J. G. (2007). Albinterferon α-2b: A genetic fusion protein for the treatment of chronic hepatitis C. Nature biotechnology, 25(12), 1411-1419. https://doi.org/10.1038/nbt1364