Albendazole Sulfoxide Plasma Levels and Efficacy of Antiparasitic Treatment in Patients with Parenchymal Neurocysticercosis

Gianfranco Arroyo, Javier A. Bustos, Andres G. Lescano, Isidro Gonzales, Herbert Saavedra, Silvia Rodriguez, E. Javier Pretell, Pierina S. Bonato, Vera L. Lanchote, Osvaldo M. Takayanagui, John Horton, Armando E. Gonzalez, Robert H. Gilman, Hector H. Garcia, Victor C.W. Tsang, Seth O'Neal, Manuel Martinez, Mirko Zimic, Manuela Verastegui, Holger MaytaYesenia Castillo, Maria T. Lopez-Urbina, Cesar M. Gavidia, Luis A. Gomez-Puerta, Luz M. Moyano, Ricardo Gamboa, Percy Vilchez, Claudio Muro, Theodore Nash, Siddartha Mahanty, John Noh, Sukwan Handali, Jon Friedland

Research output: Contribution to journalArticle

Abstract

Background: The efficacy of albendazole therapy in patients with parenchymal neurocysticercosis (NCC) is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable among patients. We hypothesized that high ASOX plasma levels during albendazole therapy may be associated with an increased antiparasitic efficacy. Methods: ASOX plasma levels were measured at treatment day 7 in 118 patients with parenchymal NCC enrolled in a treatment trial. The relationships between increasing ASOX plasma levels with the proportion of cysts resolved and the proportion of patients with complete cyst resolution (evaluated by 6-month brain magnetic resonance) were assessed. Results: There was a trend toward a higher proportion of cysts resolved and a higher proportion of patients cured with increasing quartiles of ASOX plasma levels. In patients with 3 or more brain cysts, the regression analysis adjusted by the concomitant administration of praziquantel (PZQ) showed a 2-fold increase in the proportion of cysts resolved (risk ratio [RR], 1.98; 95% confidence interval [CI], 1.01-3.89; P =. 048) and 2.5-fold increase in the proportion of patients cured (RR, 2.45; 95% CI,. 94-6.36; P =. 067) when ASOX levels in the highest vs the lowest quartile were compared. No association was found in patients with 1-2 brain cysts. Conclusions: We suggest an association between high ASOX plasma levels and increased antiparasitic efficacy in patients with parenchymal NCC. Nonetheless, this association is also influenced by other factors including parasite burden and concomitant administration of PZQ. These findings may serve to individualize and/or adjust therapy schemes to avoid treatment failure.

Original languageEnglish (US)
Pages (from-to)1996-2002
Number of pages7
JournalClinical Infectious Diseases
Volume69
Issue number11
DOIs
StatePublished - Nov 13 2019

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Keywords

  • albendazole
  • albendazole sulfoxide
  • neurocysticercosis
  • praziquantel

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Arroyo, G., Bustos, J. A., Lescano, A. G., Gonzales, I., Saavedra, H., Rodriguez, S., Pretell, E. J., Bonato, P. S., Lanchote, V. L., Takayanagui, O. M., Horton, J., Gonzalez, A. E., Gilman, R. H., Garcia, H. H., Tsang, V. C. W., O'Neal, S., Martinez, M., Zimic, M., Verastegui, M., ... Friedland, J. (2019). Albendazole Sulfoxide Plasma Levels and Efficacy of Antiparasitic Treatment in Patients with Parenchymal Neurocysticercosis. Clinical Infectious Diseases, 69(11), 1996-2002. https://doi.org/10.1093/cid/ciz085