Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness

Jochen Steppan, Huang Tran, Alexandre M. Benjo, Laxsmi Pellakuru, Viachaslau Barodka, Sungwoo Ryoo, Sinead Nyhan, Craig Lussman, Gaurav Gupta, Anthony R. White, Joao P. Daher, Artin A Shoukas, Benjamin D. Levine, Dan E Berkowitz

Research output: Contribution to journalArticle

Abstract

Advanced glycation end-products (AGEs) initiate cellular inflammation and contribute to cardiovascular disease in the elderly. AGE can be inhibited by Alagebrium (ALT), an AGE cross-link breaker. Moreover, the beneficial effects of exercise on aging are well recognized. Thus, we investigated the effects of ALT and exercise (Ex) on cardiovascular function in a rat aging model. Compared to young (Y) rats, in sedentary old (O) rats, end-systolic elastance (Ees) decreased (0.9±0.2 vs 1.7±0.4mmHg/μL, Pmax was attenuated (6054±685 vs 9540±939mmHg/s, Pmax and Ees (8945±665 vs 6054±685mmHg/s, and 1.5±0.2 vs 0.9±0.2 respectively, O with ALT+Ex vs O, P

Original languageEnglish (US)
Pages (from-to)565-572
Number of pages8
JournalExperimental Gerontology
Volume47
Issue number8
DOIs
StatePublished - Aug 2012

Fingerprint

Vascular Stiffness
Advanced Glycosylation End Products
Rats
Stiffness
Exercise
Aging of materials
Cardiovascular Diseases
Inflammation
alagebrium

Keywords

  • Advanced glycation end-products
  • AGE
  • Alagebrium
  • Exercise
  • Ventricular-vascular coupling

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness. / Steppan, Jochen; Tran, Huang; Benjo, Alexandre M.; Pellakuru, Laxsmi; Barodka, Viachaslau; Ryoo, Sungwoo; Nyhan, Sinead; Lussman, Craig; Gupta, Gaurav; White, Anthony R.; Daher, Joao P.; Shoukas, Artin A; Levine, Benjamin D.; Berkowitz, Dan E.

In: Experimental Gerontology, Vol. 47, No. 8, 08.2012, p. 565-572.

Research output: Contribution to journalArticle

Steppan, J, Tran, H, Benjo, AM, Pellakuru, L, Barodka, V, Ryoo, S, Nyhan, S, Lussman, C, Gupta, G, White, AR, Daher, JP, Shoukas, AA, Levine, BD & Berkowitz, DE 2012, 'Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness', Experimental Gerontology, vol. 47, no. 8, pp. 565-572. https://doi.org/10.1016/j.exger.2012.04.006
Steppan, Jochen ; Tran, Huang ; Benjo, Alexandre M. ; Pellakuru, Laxsmi ; Barodka, Viachaslau ; Ryoo, Sungwoo ; Nyhan, Sinead ; Lussman, Craig ; Gupta, Gaurav ; White, Anthony R. ; Daher, Joao P. ; Shoukas, Artin A ; Levine, Benjamin D. ; Berkowitz, Dan E. / Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness. In: Experimental Gerontology. 2012 ; Vol. 47, No. 8. pp. 565-572.
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