Akt stimulates aerobic glycolysis in cancer cells

Rebecca L. Elstrom, Daniel E. Bauer, Monica Buzzai, Robyn Karnauskas, Marian H. Harris, David R. Plas, Hongming Zhuang, Ryan M. Cinalli, Abass Alavi, Charles M. Rudin, Craig B. Thompson

Research output: Contribution to journalArticle

Abstract

Cancer cells frequently display high rates of aerobic glycolysis in comparison to their nontransformed counterparts, although the molecular basis of this phenomenon remains poorly understood. Constitutive activity of the serine/threonine kinase Akt is a common perturbation observed in malignant cells. Surprisingly, although Akt activity is sufficient to promote leukemogenesis in nontransformed hematopoietic precursors and maintenance of Akt activity was required for rapid disease progression, the expression of activated Akt did not increase the proliferation of the premalignant or malignant cells in culture. However, Akt stimulated glucose consumption in transformed cells without affecting the rate of oxidative phosphorylation. High rates of aerobic glycolysis were also identified in human glioblastoma cells possessing but not those lacking constitutive Akt activity. Akt-expressing cells were more susceptible than control cells to death after glucose withdrawal. These data suggest that activation of the Akt oncogene is sufficient to stimulate the switch to aerobic glycolysis characteristic of cancer cells and that Akt activity renders cancer cells dependent on aerobic glycolysis for continued growth and survival.

Original languageEnglish (US)
Pages (from-to)3892-3899
Number of pages8
JournalCancer Research
Volume64
Issue number11
DOIs
StatePublished - Jun 1 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., & Thompson, C. B. (2004). Akt stimulates aerobic glycolysis in cancer cells. Cancer Research, 64(11), 3892-3899. https://doi.org/10.1158/0008-5472.CAN-03-2904