Airways responsiveness in a population sample of adults and children

S. T. Weiss, I. B. Tager, J. W. Weiss, A. Munoz, F. E. Speizer, R. H. Ingram

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Nonspecific bronchial responsiveness was assessed with eucapneic hyperpnea to subfreezing air in a population-based sample of 134 adults and 213 children in East Boston, Massachusetts. Increased responsiveness was considered to be present if the decrease in forced expiratory volume in one second with cold air divided by the initial vital capacity was greater than 9%. Men and women had similar bronchial responsiveness, but children and young adults (24 yr of age and younger) were significantly more likely to be responders than were older subjects (p < 0.001). Children with a doctor's diagnosis of asthma at any time in the past were twice as likely (42.9%) to be responders as were nonasthmatic children (19%) (p = 0.004). Ninety-two percent (11/12) of currently active asthmatics were responders. However, a large percentage of asymptomatic children had increased levels of bronchial responsiveness (18.9%). This cross-sectional study demonstrates the feasibility of measurement of nonspecific bronchial responsiveness in epidemiologic studies, and its relationship to age and wheeze symptoms in children.

Original languageEnglish (US)
Pages (from-to)898-902
Number of pages5
JournalAmerican Review of Respiratory Disease
Issue number6
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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