TY - JOUR
T1 - Airways hyperresponsiveness and the effects of lung inflation
AU - Scichilone, Nicola
AU - Pyrgos, George
AU - Kapsali, Trigsevgeni
AU - Anderlind, Christina
AU - Brown, Robert
AU - Permutt, Solbert
AU - Togias, Alkis
PY - 2001
Y1 - 2001
N2 - Lung inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial obstruction. The bronchoprotective effect of deep inspiration is more potent than the bronchodilatory one, and the two phenomena appear to advocte different mechanisms. Asthmatics and rhinitics with airways hyperresponsiveness show an impairment in bronchoprotection induced by deep breaths, whereas the bronchodilatory effect, although reduced, is still effective. The lack of the bronchoprotective effect of deep inspiration may contribute to the development of airways hyperresponsiveness. The mechanisms through which lung inflation exerts its beneficial role in healthy subjects, and the factors impairing such an effect in those with airways hyperresponsiveness, are currently under investigation.
AB - Lung inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial obstruction. The bronchoprotective effect of deep inspiration is more potent than the bronchodilatory one, and the two phenomena appear to advocte different mechanisms. Asthmatics and rhinitics with airways hyperresponsiveness show an impairment in bronchoprotection induced by deep breaths, whereas the bronchodilatory effect, although reduced, is still effective. The lack of the bronchoprotective effect of deep inspiration may contribute to the development of airways hyperresponsiveness. The mechanisms through which lung inflation exerts its beneficial role in healthy subjects, and the factors impairing such an effect in those with airways hyperresponsiveness, are currently under investigation.
KW - Airways hyperresponsiveness
KW - Asthma
KW - Bronchoprovocation
KW - Lung function
KW - Lung inflation
KW - Methacholine
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U2 - 10.1159/000053728
DO - 10.1159/000053728
M3 - Article
C2 - 11306986
AN - SCOPUS:0035045024
SN - 1018-2438
VL - 124
SP - 262
EP - 266
JO - International archives of allergy and immunology
JF - International archives of allergy and immunology
IS - 1-3
ER -