Airways hyperresponsiveness and the effects of lung inflation

Nicola Scichilone, George Pyrgos, Trigsevgeni Kapsali, Christina Anderlind, Robert Brown, Solbert Permutt, Alkis Togias

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Lung inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial obstruction. The bronchoprotective effect of deep inspiration is more potent than the bronchodilatory one, and the two phenomena appear to advocte different mechanisms. Asthmatics and rhinitics with airways hyperresponsiveness show an impairment in bronchoprotection induced by deep breaths, whereas the bronchodilatory effect, although reduced, is still effective. The lack of the bronchoprotective effect of deep inspiration may contribute to the development of airways hyperresponsiveness. The mechanisms through which lung inflation exerts its beneficial role in healthy subjects, and the factors impairing such an effect in those with airways hyperresponsiveness, are currently under investigation.

Original languageEnglish (US)
Pages (from-to)262-266
Number of pages5
JournalInternational archives of allergy and immunology
Issue number1-3
StatePublished - 2001


  • Airways hyperresponsiveness
  • Asthma
  • Bronchoprovocation
  • Lung function
  • Lung inflation
  • Methacholine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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