Airway responses to methacholine in allergic and nonallergic subjects

J. E. Fish, R. R. Rosenthal, G. Batra, H. Menkes, W. Summer, S. Permutt, P. Norman

Research output: Contribution to journalArticlepeer-review


After inhalation challenge with methacholine, bronchoconstrictor responses were produced in allergic subjects with asthma and hay fever as well as nonallergic subjects. The authors' results indicate that allergic persons possess a greater pulmonary responsiveness to inhalation of this parasympathomimetic agent than nonallergic subjects; however, patterns of response were different in the 2 types of allergic subjects, those with asthma and those with hay fever. Whereas both types of allergic subjects responded with changes in specific airway conductance when nonallergic subjects did not, only 3 wk subjects differed from nonallergic subjects when comparisons of spirometry were made. These data suggest that there is hypersensitivity of both central and peripheral airways in asthmatics and in the larger central airways of nonasthmatic allergic subjects.

Original languageEnglish (US)
Pages (from-to)579-586
Number of pages8
JournalAmerican Review of Respiratory Disease
Issue number5
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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