Airway remodelling in the transplanted lung

Mark Kuehnel, Lavinia Maegel, Jens Vogel-Claussen, Jan Lukas Robertus, Danny Jonigk

Research output: Contribution to journalArticle

Abstract

Following lung transplantation, fibrotic remodelling of the small airways has been recognized for almost 5 decades as the main correlate of chronic graft failure and a major obstacle to long-term survival. Mainly due to airway fibrosis, pulmonary allografts currently show the highest attrition rate of all solid organ transplants, with a 5-year survival rate of 58 % on a worldwide scale. The observation that these morphological changes are not just the hallmark of chronic rejection but rather represent a manifestation of a multitude of alloimmune-dependent and -independent injuries was made more recently, as was the discovery that chronic lung allograft dysfunction manifests in different clinical phenotypes of respiratory impairment and corresponding morphological subentities. Although recent years have seen considerable advances in identifying and categorizing these subgroups on the basis of clinical, functional and histomorphological changes, as well as susceptibility to medicinal treatment, this process is far from over. Since the actual pathophysiological mechanisms governing airway remodelling are still only poorly understood, diagnosis and therapy of chronic lung allograft dysfunction presents a major challenge to clinicians, radiologists and pathologists alike. Here, we review and discuss the current state of the literature on chronic lung allograft dysfunction and shed light on classification systems, corresponding clinical and morphological changes, key cellular players and underlying molecular pathways, as well as on emerging diagnostic and therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalCell and Tissue Research
DOIs
StateAccepted/In press - Nov 12 2016
Externally publishedYes

Fingerprint

Airway Remodeling
Allografts
Lung
Transplants
Lung Transplantation
Pulmonary Fibrosis
Therapeutics
Phenotype
Wounds and Injuries

Keywords

  • Bronchiolitis obliterans
  • Chronic lung allograft dysfunction
  • Chronic rejection
  • Lung transplantation
  • Obliterative airway remodelling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Kuehnel, M., Maegel, L., Vogel-Claussen, J., Robertus, J. L., & Jonigk, D. (Accepted/In press). Airway remodelling in the transplanted lung. Cell and Tissue Research, 1-13. https://doi.org/10.1007/s00441-016-2529-0

Airway remodelling in the transplanted lung. / Kuehnel, Mark; Maegel, Lavinia; Vogel-Claussen, Jens; Robertus, Jan Lukas; Jonigk, Danny.

In: Cell and Tissue Research, 12.11.2016, p. 1-13.

Research output: Contribution to journalArticle

Kuehnel, M, Maegel, L, Vogel-Claussen, J, Robertus, JL & Jonigk, D 2016, 'Airway remodelling in the transplanted lung', Cell and Tissue Research, pp. 1-13. https://doi.org/10.1007/s00441-016-2529-0
Kuehnel M, Maegel L, Vogel-Claussen J, Robertus JL, Jonigk D. Airway remodelling in the transplanted lung. Cell and Tissue Research. 2016 Nov 12;1-13. https://doi.org/10.1007/s00441-016-2529-0
Kuehnel, Mark ; Maegel, Lavinia ; Vogel-Claussen, Jens ; Robertus, Jan Lukas ; Jonigk, Danny. / Airway remodelling in the transplanted lung. In: Cell and Tissue Research. 2016 ; pp. 1-13.
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