Airway Remodeling Factors During Early-Life Rhinovirus Infection and the Effect of Premature Birth

Xilei XuChen, Jered Weinstock, Maria Arroyo, Kyle Salka, Elizabeth Chorvinsky, Karima Abutaleb, Hector Aguilar, Ryan Kahanowitch, Carlos E. Rodríguez-Martínez, Geovanny F. Perez, Maria J. Gutierrez, Gustavo Nino

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Early rhinovirus (RV) infection is a strong risk factor for asthma development. Airway remodeling factors play a key role in the progression of the asthmatic condition. We hypothesized that RV infection in young children elicits the secretion of growth factors implicated in airway remodeling and asthma progression. Methods: We examined the nasal airway production of remodeling factors in children (≤ 2 years old) hospitalized due to PCR-confirmed RV infection. Airway remodeling proteins included: MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, TIMP-2, EGF, Angiopoietin-2, G-CSF, BMP-9, Endoglin, Endothelin-1, Leptin, FGF-1, Follistatin, HGF, HB-EGF, PLGF, VEGF-A, VEGF-C, VEGF-D, FGF-2, TGF-β1, TGF-β2, TGF-β3, PDGF AA, PDGF BB, SPARC, Periostin, OPN, and TGF-α. Results: A total of 43 young children comprising RV cases (n = 26) and uninfected controls (n = 17) were included. Early RV infection was linked to (1) enhanced production of several remodeling factors (e.g., HGF, TGFα), (2) lower MMP-9/TIMP-2 and MMP-2/TIMP-2 ratios, and (3) increased MMP-10/TIMP-1 ratios. We also found that relative to term infants, severely premature children had reduced MMP-9/TIMP-2 ratios at baseline. Conclusion: RV infection in young children elicits the airway secretion of growth factors implicated in angiogenesis, fibrosis, and extracellular matrix deposition. Our results highlight the potential of investigating virus-induced airway remodeling growth factors during early infancy to monitor and potentially prevent chronic progression of respiratory disorders in all ages.

Original languageEnglish (US)
Article number610478
JournalFrontiers in Pediatrics
Volume9
DOIs
StatePublished - Feb 26 2021

Keywords

  • airway remodeling
  • growth factor
  • infancy
  • prematurity
  • rhinovirus (RV)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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