@article{99b569cd22194c44b7f97b0aad97818f,
title = "Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese",
abstract = "Background: Few studies have examined how developing obesity in early adulthood affects the course of asthma. Objective: We analyzed lung function and asthma impairment and risk among nonobese children with asthma, comparing those who were obese in young adulthood with those who remained nonobese. Methods: We carried out the post hoc analysis of 771 subjects with mild to moderate asthma who were not obese (pediatric definition, body mass index [BMI] < 95th percentile) when enrolled in the Childhood Asthma Management Program at ages 5-12 years. The subjects were then followed to age 20 years or more. For visits at ages 20 years or more, spirometry values as percent predicted and recent asthma symptom scores and prednisone exposure were compared between 579 subjects who were nonobese at all visits and 151 who were obese (adult definition of BMI ≥ 30 kg/m2) on at least 1 visit (median number of visits when obese = 4, IQR 2-7). Results: Compared with participants who were nonobese (BMI 23.4 ± 2.6 kg/m2), those who became obese (BMI 31.5 ± 3.8 kg/m2) had significant decreases in forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) (P < .0003) and FEV1 (P = .001), without differences in FVC (P = .15) during visits at ages 20 years or more. For each unit increase of BMI, FEV1 percent predicted decreased by 0.29 (P = .0009). The relationship between BMI and lung function was not confounded by sex or BMI at baseline. Asthma impairment (symptom scores) and risk (prednisone use) did not differ between the 2 groups. Conclusion: Becoming obese in early adulthood was associated with increased airway obstruction, without impact on asthma impairment or risk.",
keywords = "Childhood asthma, Childhood obesity, Obese asthma, Pulmonary function",
author = "{Childhood Asthma Management Program Research Group} and Strunk, {Robert C.} and Ryan Colvin and Bacharier, {Leonard B.} and Anne Fuhlbrigge and Erick Forno and Arbelaez, {Ana Maria} and Tantisira, {Kelan G.} and Paul Williams and Lasley, {Mary V.} and Tamara Chinn and Michele Hinatsu and Furukawa, {Clifton T.} and Altman, {Leonard C.} and Virant, {Frank S.} and Kennedy, {Michael S.} and Stephen Tilles and Becker, {Jonathan W.} and Bierman, {C. Warren} and Dan Crawford and Thomas DuHamel and Heather Eliassen and Babi Hammond and Miranda MacLaren and Minotti, {Dominick A.} and Chris Reagan and Gail Shapiro and Marian Sharpe and Ashley Tatum and Grace White and Wighton, {Timothy G.} and Anne Plunkett and Nancy Madden and Susan Anderson and Mark Boehnert and Anita Feins and Amanda Gentile and Natalia Kandror and Kelly MacAulay and Adkinson, {N. Franklin} and Peyton Eggleston and Karen Huss and Leslie Plotnick and Cynthia Rand and James Tonascia and Sternberg, {Alice L.} and {Van Natta}, {Mark L.} and Laura Wilson and Robert Wise and Katherine Yates and Meinert, {Curtis L.}",
note = "Funding Information: The Childhood Asthma Management Program trial and CAMP Continuation Study were supported by contracts NO1-HR-16044, 16045, 16046, 16047, 16048, 16049, 16050, 16051, and 16052 with the National Heart, Lung, and Blood Institute and General Clinical Research Center grants M01RR00051 , M01RR0099718-24 , M01RR02719-14 , and RR00036 from the National Center for Research Resources . The CAMP Continuation Study/Phases 2 and 3 were supported by grants U01HL075232 , U01HL075407 , U01HL075408 , U01HL075409 , U01HL075415 , U01HL075416 , U01HL075417 , U01HL075419 , U01HL075420 , and U01HL075408 from the National Heart, Lung, and Blood Institute . The National Jewish Health site was also supported in part by Colorado CTSA grant UL1RR025780 from NCRR/NIH and UL1TR000154 from NCATS/NIH . ",
year = "2015",
month = sep,
day = "1",
doi = "10.1016/j.jaip.2015.05.009",
language = "English (US)",
volume = "3",
pages = "765--771.e2",
journal = "Journal of Allergy and Clinical Immunology: In Practice",
issn = "2213-2198",
publisher = "Elsevier",
number = "5",
}