Abstract
Background: Few studies have examined how developing obesity in early adulthood affects the course of asthma. Objective: We analyzed lung function and asthma impairment and risk among nonobese children with asthma, comparing those who were obese in young adulthood with those who remained nonobese. Methods: We carried out the post hoc analysis of 771 subjects with mild to moderate asthma who were not obese (pediatric definition, body mass index [BMI] <95th percentile) when enrolled in the Childhood Asthma Management Program at ages 5-12 years. The subjects were then followed to age 20 years or more. For visits at ages 20 years or more, spirometry values as percent predicted and recent asthma symptom scores and prednisone exposure were compared between 579 subjects who were nonobese at all visits and 151 who were obese (adult definition of BMI ≥ 30 kg/m2) on at least 1 visit (median number of visits when obese = 4, IQR 2-7). Results: Compared with participants who were nonobese (BMI 23.4 ± 2.6 kg/m2), those who became obese (BMI 31.5 ± 3.8 kg/m2) had significant decreases in forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) (P <.0003) and FEV1 (P = .001), without differences in FVC (P = .15) during visits at ages 20 years or more. For each unit increase of BMI, FEV1 percent predicted decreased by 0.29 (P = .0009). The relationship between BMI and lung function was not confounded by sex or BMI at baseline. Asthma impairment (symptom scores) and risk (prednisone use) did not differ between the 2 groups. Conclusion: Becoming obese in early adulthood was associated with increased airway obstruction, without impact on asthma impairment or risk.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 765-771.e2 |
| Journal | Journal of Allergy and Clinical Immunology: In Practice |
| Volume | 3 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2015 |
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Keywords
- Childhood asthma
- Childhood obesity
- Obese asthma
- Pulmonary function
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese. / Childhood Asthma Management Program Research Group; Eggleston, Peyton; Plotnick, Leslie.
In: Journal of Allergy and Clinical Immunology: In Practice, Vol. 3, No. 5, 01.09.2015, p. 765-771.e2.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese
AU - Childhood Asthma Management Program Research Group
AU - Strunk, Robert C.
AU - Colvin, Ryan
AU - Bacharier, Leonard B.
AU - Fuhlbrigge, Anne
AU - Forno, Erick
AU - Arbelaez, Ana Maria
AU - Tantisira, Kelan G.
AU - Williams, Paul
AU - Lasley, Mary V.
AU - Chinn, Tamara
AU - Hinatsu, Michele
AU - Furukawa, Clifton T.
AU - Altman, Leonard C.
AU - Virant, Frank S.
AU - Kennedy, Michael S.
AU - Tilles, Stephen
AU - Becker, Jonathan W.
AU - Bierman, C. Warren
AU - Crawford, Dan
AU - DuHamel, Thomas
AU - Eliassen, Heather
AU - Hammond, Babi
AU - MacLaren, Miranda
AU - Minotti, Dominick A.
AU - Reagan, Chris
AU - Shapiro, Gail
AU - Sharpe, Marian
AU - Tatum, Ashley
AU - White, Grace
AU - Wighton, Timothy G.
AU - Plunkett, Anne
AU - Madden, Nancy
AU - Anderson, Susan
AU - Boehnert, Mark
AU - Feins, Anita
AU - Gentile, Amanda
AU - Kandror, Natalia
AU - MacAulay, Kelly
AU - Eggleston, Peyton
AU - Weiss, Scott
AU - Plotnick, Leslie
AU - Huss, Karen
AU - Rand, Cynthia S
AU - Tonascia, James A
AU - Sternberg, Alice L
AU - Van Natta, Mark L
AU - Wilson, Laura
AU - Wise, Robert A
AU - Yates, Katherine
AU - Meinert, Curtis L
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background: Few studies have examined how developing obesity in early adulthood affects the course of asthma. Objective: We analyzed lung function and asthma impairment and risk among nonobese children with asthma, comparing those who were obese in young adulthood with those who remained nonobese. Methods: We carried out the post hoc analysis of 771 subjects with mild to moderate asthma who were not obese (pediatric definition, body mass index [BMI] <95th percentile) when enrolled in the Childhood Asthma Management Program at ages 5-12 years. The subjects were then followed to age 20 years or more. For visits at ages 20 years or more, spirometry values as percent predicted and recent asthma symptom scores and prednisone exposure were compared between 579 subjects who were nonobese at all visits and 151 who were obese (adult definition of BMI ≥ 30 kg/m2) on at least 1 visit (median number of visits when obese = 4, IQR 2-7). Results: Compared with participants who were nonobese (BMI 23.4 ± 2.6 kg/m2), those who became obese (BMI 31.5 ± 3.8 kg/m2) had significant decreases in forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) (P <.0003) and FEV1 (P = .001), without differences in FVC (P = .15) during visits at ages 20 years or more. For each unit increase of BMI, FEV1 percent predicted decreased by 0.29 (P = .0009). The relationship between BMI and lung function was not confounded by sex or BMI at baseline. Asthma impairment (symptom scores) and risk (prednisone use) did not differ between the 2 groups. Conclusion: Becoming obese in early adulthood was associated with increased airway obstruction, without impact on asthma impairment or risk.
AB - Background: Few studies have examined how developing obesity in early adulthood affects the course of asthma. Objective: We analyzed lung function and asthma impairment and risk among nonobese children with asthma, comparing those who were obese in young adulthood with those who remained nonobese. Methods: We carried out the post hoc analysis of 771 subjects with mild to moderate asthma who were not obese (pediatric definition, body mass index [BMI] <95th percentile) when enrolled in the Childhood Asthma Management Program at ages 5-12 years. The subjects were then followed to age 20 years or more. For visits at ages 20 years or more, spirometry values as percent predicted and recent asthma symptom scores and prednisone exposure were compared between 579 subjects who were nonobese at all visits and 151 who were obese (adult definition of BMI ≥ 30 kg/m2) on at least 1 visit (median number of visits when obese = 4, IQR 2-7). Results: Compared with participants who were nonobese (BMI 23.4 ± 2.6 kg/m2), those who became obese (BMI 31.5 ± 3.8 kg/m2) had significant decreases in forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) (P <.0003) and FEV1 (P = .001), without differences in FVC (P = .15) during visits at ages 20 years or more. For each unit increase of BMI, FEV1 percent predicted decreased by 0.29 (P = .0009). The relationship between BMI and lung function was not confounded by sex or BMI at baseline. Asthma impairment (symptom scores) and risk (prednisone use) did not differ between the 2 groups. Conclusion: Becoming obese in early adulthood was associated with increased airway obstruction, without impact on asthma impairment or risk.
KW - Childhood asthma
KW - Childhood obesity
KW - Obese asthma
KW - Pulmonary function
UR - http://www.scopus.com/inward/record.url?scp=84941260396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941260396&partnerID=8YFLogxK
U2 - 10.1016/j.jaip.2015.05.009
DO - 10.1016/j.jaip.2015.05.009
M3 - Article
C2 - 26164807
AN - SCOPUS:84941260396
VL - 3
SP - 765-771.e2
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
SN - 2213-2198
IS - 5
ER -