Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone

Alfonso Torres, Mark J. Utell, Paul E. Morow, Karen Z. Voter, John C. Whitin, Christopher Cox, R. John Looney, Donna M. Speers, Ying Tsai, Mark W. Frampton

Research output: Contribution to journalArticle

Abstract

Exposure to ozone causes symptoms, changes in lung function, and airway inflammation. We studied whether individuals who differ in lung-function responsiveness to ozone, or in smoking status, also differ in susceptibility to airway inflammation. Healthy subjects were selected on the basis of responsiveness to a classifying exposure to 0.22 ppm ozone for 4 h with exercise (responders, with a decrease in FEV1 > 15%; and nonresponders, with a decrease in FEV1 <5%). Three groups were studied: nonsmoker-nonresponders (n = 12), nonsmoker-responders (n = 13), and smokers (n = 13, 11 nonresponders and two responders). Each subject underwent two exposures to ozone and one to air, separated by at least 3 wk; bronchoalveolar and nasal lavages were performed on three occasions: immediately (early) and 18 h (late) after ozone exposure, and either early or late after air exposure. Recovery of polymorphonuclear leukocytes (PMN) increased progressively in all groups, and by up to 6-fold late after ozone exposure. Interleukin-6 (IL-6) and IL-8 increased early (by up to 10-fold and up to 2-fold, respectively), and correlated with the late increase in PMN. Lymphocytes, mast cells, and eosinophils also increased late after exposure. We conclude that ozone- induced airway inflammation is independent of smoking status or airway responsiveness to ozone.

Original languageEnglish (US)
Pages (from-to)728-736
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume156
Issue number3 I
StatePublished - 1997
Externally publishedYes

Fingerprint

Ozone
Inflammation
Neutrophils
Smoking
Air
Nasal Lavage
Lung
Bronchoalveolar Lavage
Interleukin-8
Eosinophils
Mast Cells
Interleukin-6
Healthy Volunteers
Lymphocytes
Exercise

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Torres, A., Utell, M. J., Morow, P. E., Voter, K. Z., Whitin, J. C., Cox, C., ... Frampton, M. W. (1997). Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. American Journal of Respiratory and Critical Care Medicine, 156(3 I), 728-736.

Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. / Torres, Alfonso; Utell, Mark J.; Morow, Paul E.; Voter, Karen Z.; Whitin, John C.; Cox, Christopher; Looney, R. John; Speers, Donna M.; Tsai, Ying; Frampton, Mark W.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 156, No. 3 I, 1997, p. 728-736.

Research output: Contribution to journalArticle

Torres, A, Utell, MJ, Morow, PE, Voter, KZ, Whitin, JC, Cox, C, Looney, RJ, Speers, DM, Tsai, Y & Frampton, MW 1997, 'Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone', American Journal of Respiratory and Critical Care Medicine, vol. 156, no. 3 I, pp. 728-736.
Torres, Alfonso ; Utell, Mark J. ; Morow, Paul E. ; Voter, Karen Z. ; Whitin, John C. ; Cox, Christopher ; Looney, R. John ; Speers, Donna M. ; Tsai, Ying ; Frampton, Mark W. / Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. In: American Journal of Respiratory and Critical Care Medicine. 1997 ; Vol. 156, No. 3 I. pp. 728-736.
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