Airway imaging in humans using hyperpolarized helium-3 MRI

E. L. McKinstry, A. C. Tooker, K. S. Hong, P. Costello, F. A. Jolesz, M. S. Albert

Research output: Contribution to journalConference article

Abstract

Most hyperpolarized gas MRI, involving dynamic imaging of the human lungs, requires specialized ultra-fast MRI pulse sequences or the necessity for multiple breaths of hyperpolarized helium. Thus, most current dynamic imaging techniques are not ideal for a clinical setting. By using a standard Fast GRE pulse sequence on a GE Signa 1.5 T clinical MRI scanner outfitted with heterodyne functionality, we have developed a clinically feasible method for dynamic human lung imaging of the airways. The technique presented here exploits the non-renewability of hyperpolarized gas to achieve the first distal human airway images with up to 7th generation resolution of airways. Additionally, this approach requires only a single inspiration of hyperpolarized helium. The airway images achieved may provide unique information about possible causes of pulmonary airway constriction diseases.

Original languageEnglish (US)
Pages (from-to)923-924
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2002
Externally publishedYes
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Hyperpolarized gas
  • MRI
  • Pulmonary imaging

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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