Airway imaging in humans using hyperpolarized helium-3 MRI

E. L. McKinstry, A. C. Tooker, K. S. Hong, P. Costello, F. A. Jolesz, Marilyn Albert

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Most hyperpolarized gas MRI, involving dynamic imaging of the human lungs, requires specialized ultra-fast MRI pulse sequences or the necessity for multiple breaths of hyperpolarized helium. Thus, most current dynamic imaging techniques are not ideal for a clinical setting. By using a standard Fast GRE pulse sequence on a GE Signa 1.5 T clinical MRI scanner outfitted with heterodyne functionality, we have developed a clinically feasible method for dynamic human lung imaging of the airways. The technique presented here exploits the non-renewability of hyperpolarized gas to achieve the first distal human airway images with up to 7th generation resolution of airways. Additionally, this approach requires only a single inspiration of hyperpolarized helium. The airway images achieved may provide unique information about possible causes of pulmonary airway constriction diseases.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages923-924
Number of pages2
Volume2
StatePublished - 2002
Externally publishedYes
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Other

OtherProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)
CountryUnited States
CityHouston, TX
Period10/23/0210/26/02

Fingerprint

Helium
Magnetic resonance imaging
Imaging techniques
Gases

Keywords

  • Hyperpolarized gas
  • MRI
  • Pulmonary imaging

ASJC Scopus subject areas

  • Bioengineering

Cite this

McKinstry, E. L., Tooker, A. C., Hong, K. S., Costello, P., Jolesz, F. A., & Albert, M. (2002). Airway imaging in humans using hyperpolarized helium-3 MRI. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 923-924)

Airway imaging in humans using hyperpolarized helium-3 MRI. / McKinstry, E. L.; Tooker, A. C.; Hong, K. S.; Costello, P.; Jolesz, F. A.; Albert, Marilyn.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 2002. p. 923-924.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

McKinstry, EL, Tooker, AC, Hong, KS, Costello, P, Jolesz, FA & Albert, M 2002, Airway imaging in humans using hyperpolarized helium-3 MRI. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, pp. 923-924, Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS), Houston, TX, United States, 10/23/02.
McKinstry EL, Tooker AC, Hong KS, Costello P, Jolesz FA, Albert M. Airway imaging in humans using hyperpolarized helium-3 MRI. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. 2002. p. 923-924
McKinstry, E. L. ; Tooker, A. C. ; Hong, K. S. ; Costello, P. ; Jolesz, F. A. ; Albert, Marilyn. / Airway imaging in humans using hyperpolarized helium-3 MRI. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 2002. pp. 923-924
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