Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis

Victoria L. Campodónico, Mihaela Gadjeva, Catherine Paradis-Bleau, Ahmet Uluer, Gerald B. Pier

Research output: Contribution to journalReview articlepeer-review

Abstract

Defective expression or function of the cystic fibrosis transmembrane conductance regulator (CFTR) underlies the hypersusceptibility of cystic fibrosis (CF) patients to chronic airway infections, particularly with Pseudomonas aeruginosa. CFTR is involved in the specific recognition of P. aeruginosa, thereby contributing to effective innate immunity and proper hydration of the airway surface layer (ASL). In CF, the airway epithelium fails to initiate an appropriate innate immune response, allowing the microbe to bind to mucus plugs that are then not properly cleared because of the dehydrated ASL. Recent studies have identified numerous CFTR-dependent factors that are recruited to the epithelial plasma membrane in response to infection and that are needed for bacterial clearance, a process that is defective in CF patients hypersusceptible to infection with this organism.

Original languageEnglish (US)
Pages (from-to)120-133
Number of pages14
JournalTrends in Molecular Medicine
Volume14
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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